Department of Biomedical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA.
Department of Community Medicine, Mercer University School of Medicine, Macon, GA 31207, USA.
Reprod Toxicol. 2020 Apr;93:137-145. doi: 10.1016/j.reprotox.2020.02.005. Epub 2020 Feb 19.
Chronic kidney disease (CKD) affects over 15 % of the adults in the United States. Pregnant women with CKD present an additional challenge in that they are at increased risk for adverse events such as preterm birth. Exposure to environmental toxicants, such as methylmercury, may exacerbate maternal disease and increase the risk of adverse fetal outcomes. We hypothesized that fetuses of mothers with CKD are more susceptible to accumulation of methylmercury than fetuses of healthy mothers. The current data show that when mothers are in a state of renal insufficiency, uptake of mercury in fetal kidneys is enhanced significantly. Accumulation of Hg in fetal kidneys may be related to the flow of amniotic fluid, maternal handling of Hg, and/or underdeveloped mechanisms for cellular export and urinary excretion. The results of this study indicate that renal insufficiency in mothers leads to significant alterations in the way toxicants such as mercury are handled by maternal and fetal organs.
慢性肾脏病（CKD）影响了美国超过 15%的成年人。患有 CKD 的孕妇带来了额外的挑战，因为她们面临着早产等不良事件的风险增加。接触环境毒素，如甲基汞，可能会使母体疾病恶化，并增加不良胎儿结局的风险。我们假设患有 CKD 的母亲的胎儿比健康母亲的胎儿更容易积累甲基汞。目前的数据表明，当母亲处于肾功能不全状态时，胎儿肾脏对汞的摄取显著增强。Hg 在胎儿肾脏中的积累可能与羊水的流动、母体对 Hg 的处理以及/或者细胞外排和尿液排泄的发育不完善的机制有关。这项研究的结果表明，母亲的肾功能不全导致母体和胎儿器官处理汞等毒素的方式发生了重大变化。
