Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Michael E DeBakey VA Medical Center, Houston, TX, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; The Menninger Clinic, Houston, TX, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jun 8;100:109890. doi: 10.1016/j.pnpbp.2020.109890. Epub 2020 Feb 19.
Previous magnetic resonance imaging studies of post-traumatic stress disorder (PTSD) have reported cortical volume alterations in the parahippocampal, anterior cingulate cortex, and temporal pole. It is unclear, however, if these cortical regions are specifically associated with PTSD or associated with common comorbidities. Here, we present the result of cortical volume differences between PTSD and healthy and psychiatric controls. In this study, healthy controls (n = 67) were matched for demographic characteristics (age, sex, race) and psychiatric controls (n = 67) were matched for demographic characteristics plus all other psychiatric diagnoses (past and current) to a group of PTSD patients (N = 67). We assessed group differences of 34 bilateral cortical structure volumes using statistically defined brain regions-of-interest from FreeSurfer between PTSD patients and healthy controls. We found 10 regions to be significantly different between PTSD and healthy controls and analyzed the group differences between PTSD and psychiatric controls within these regions. The right temporal pole volume in PTSD was found to be significantly smaller than both healthy and psychiatry controls. Our finding suggests only right temporal pole volume reduction is specifically associated with PTSD, and also highlights the need for using appropriate controls in psychiatry research.
先前有关创伤后应激障碍 (PTSD) 的磁共振成像研究报告称，海马旁回、前扣带皮层和颞极存在皮质体积改变。然而，这些皮质区域是否与 PTSD 特异性相关，或者是否与常见的共病相关尚不清楚。在这里，我们展示了 PTSD 与健康和精神病对照者之间皮质体积差异的结果。在这项研究中，健康对照组（n=67）在人口统计学特征（年龄、性别、种族）上与 PTSD 患者（n=67）相匹配，精神病对照组（n=67）在人口统计学特征加上所有其他精神科诊断（过去和现在）上与 PTSD 患者相匹配。我们使用 FreeSurfer 从统计上定义的大脑感兴趣区域评估了 PTSD 患者与健康对照组之间 34 个双侧皮质结构体积的组间差异。我们发现 PTSD 与健康对照组之间有 10 个区域存在显著差异，并在这些区域内分析了 PTSD 与精神病对照组之间的组间差异。PTSD 患者的右侧颞极体积明显小于健康对照组和精神病对照组。我们的发现表明，只有右侧颞极体积减少与 PTSD 特异性相关，这也强调了在精神病学研究中使用适当对照的必要性。
