miR-155 在感染鼠衣原体的肺部中的作用
The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs.
机构信息
South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
出版信息
Microbes Infect. 2020 Sep;22(8):360-365. doi: 10.1016/j.micinf.2020.02.005. Epub 2020 Feb 19.
Abstract
Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.
摘要
我们实验室研究了一种进化上保守的 RNA 物种——microRNAs（miRs）在调节抗衣原体保护性免疫中的作用。在特定的免疫效应细胞中表达的 miR-155 等 miR 对于抗原特异性保护性免疫和 IFN-γ 的产生至关重要。使用 miR-155 缺陷小鼠和衣原体感染的小鼠肺部模型，我们在此报告 1）宿主 miR-155 对细菌负荷的影响，以及 2）鉴定可能受 miR-155 调控的免疫基因。
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