微小 RNA 介导的对革兰氏阴性菌免疫的调节。
MicroRNA mediated regulation of immunity against gram-negative bacteria.
机构信息
a South Texas Center for Emerging Infectious Diseases and Center of Excellence in Infection Genomics , University of Texas at San Antonio , One UTSA Circle, San Antonio , TX.
b Department of Molecular and Integrative Physiology , University of Kansas Medical Center , Kansas City , Kansas.
出版信息
Int Rev Immunol. 2017 Sep 3;36(5):287-299. doi: 10.1080/08830185.2017.1347649. Epub 2017 Aug 11.
Abstract
Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.
摘要
过去几十年的证据已经全面证实，短的、高度保守的非编码 RNA 物种，称为 microRNA (miRNA)，具有在信使 RNA (mRNA) 水平调节宿主基因表达和功能的能力。microRNAs 在免疫细胞的发育、分化和保护功能中发挥关键的调节作用。宿主对入侵病原体的固有免疫反应依赖于先天和适应性免疫分支发展中的复杂协调事件。我们在这篇综述中讨论了 miRNA 在调节这些针对革兰氏阴性病原体的过程中的作用。
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