Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou 325000, China.
Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
Int J Mol Sci. 2020 Feb 18;21(4):1375. doi: 10.3390/ijms21041375.
Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays an important role in multiple stress-related mental disorders. Although alterations in BDNF in multiple brain regions of individuals experiencing stress have been demonstrated in previous studies, it appears that a set of elements are involved in the complex regulation. In this review, we summarize the specific brain regions with altered BDNF expression during stress exposure. How various environmental factors, including both physical and psychological stress, affect the expression of BDNF in specific brain regions are further summarized. Moreover, epigenetic regulation of BDNF, including DNA methylation, histone modification, and noncoding RNA, in response to diverse types of stress, as well as sex differences in the sensitivity of BDNF to the stress response, is also summarized. Clarification of the underlying role of BDNF in the stress process will promote our understanding of the pathology of stress-linked mental disorders and provide a potent target for the future treatment of stress-related illness.
脑源性神经营养因子（BDNF）是神经营养因子家族的重要成员，在多种与应激相关的精神障碍中发挥重要作用。尽管之前的研究已经证明了经历应激的个体多个脑区中 BDNF 的改变，但似乎有一组元素参与了这种复杂的调节。在这篇综述中，我们总结了在应激暴露期间 BDNF 表达改变的特定脑区。进一步总结了各种环境因素（包括生理和心理应激）如何影响特定脑区中 BDNF 的表达。此外，还总结了 BDNF 的表观遗传调控，包括 DNA 甲基化、组蛋白修饰和非编码 RNA，以及 BDNF 对不同类型应激的反应以及性别差异对 BDNF 对应激反应的敏感性。阐明 BDNF 在应激过程中的作用将促进我们对与应激相关的精神障碍发病机制的理解，并为未来应激相关疾病的治疗提供一个有效的靶点。
