Department of Cognitive Neuroscience, Radboud university medical center, 6500 HB Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, the Netherlands.
Department of Cognitive Neuroscience, Radboud university medical center, 6500 HB Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, the Netherlands.
Psychoneuroendocrinology. 2020 Apr;114:104588. doi: 10.1016/j.psyneuen.2020.104588. Epub 2020 Jan 25.
Stressful and emotionally arousing experiences activate hormonal systems that create strong memories. It remains unclear, however, how this strengthening affects the quality of such memories. In the present study, we examined whether the noradrenergic and glucocorticoid hormonal systems affect accuracy of episodic-like memory. We trained male Sprague-Dawley rats on an episodic-like association task, termed inhibitory avoidance discrimination task, in which they explored two different contexts, but shock was given only in the latter context. Forty-eight hours later, retention latencies were tested in the two training contexts as well as in a novel context. The noradrenergic stimulant yohimbine, administered systemically immediately after the training session, enhanced both accuracy and strength of the memory, as shown by long latencies specific to the shock context. By contrast, the glucocorticoid corticosterone induced a generalized strengthening of memory and enhanced latencies in both the shock and non-shock training contexts. Retention latencies in the novel context were not significantly affected. These findings indicate that the noradrenergic and glucocorticoid systems, while both strengthening memory of the shock experience per se, produce opposite effects on accuracy of the shock-context association.
压力和情绪激发的体验会激活激素系统，从而产生强烈的记忆。然而，这种增强如何影响此类记忆的质量尚不清楚。在本研究中，我们研究了去甲肾上腺素能和糖皮质激素系统是否会影响情景式记忆的准确性。我们在一种称为抑制回避辨别任务的情景式关联任务中对雄性 Sprague-Dawley 大鼠进行训练，在该任务中，它们探索了两个不同的环境，但仅在后一个环境中给予电击。48 小时后，在两个训练环境以及一个新环境中测试保留潜伏期。在训练后立即系统给予去甲肾上腺素兴奋剂育亨宾，增强了记忆的准确性和强度，表现为对电击环境的特定长潜伏期。相比之下，糖皮质激素皮质酮导致记忆的普遍增强，并延长了电击和非电击训练环境中的潜伏期。在新环境中的保留潜伏期没有显著影响。这些发现表明，去甲肾上腺素能和糖皮质激素系统虽然都增强了电击体验本身的记忆，但对电击环境关联的准确性产生了相反的影响。
