Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Escuela de Nutrición, CENINH, Córdoba, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, INICSA, Córdoba, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, INICSA, Córdoba, Argentina.
Arch Med Res. 2020 Jan;51(1):8-12. doi: 10.1016/j.arcmed.2019.11.006. Epub 2020 Feb 18.
Lung adenocarcinoma (LAC) is a major worldwide cause of death by cancer, it shows high aggressiveness, functional decline, systemic compromise and severe cachexia, which might be counteracted by dietary redox-active phytochemicals. Therefore, our aim was to establish the anticancer effects of the oral intake of quercetin and 5 caffeoylquinic acid.
LAC-1-bearing male Balb/c mice received quercetin (0-25 μg/kg/d) and 5 caffeoylquinic acid (0-120 μg/kg/d) for three weeks, with different organic and biochemical variables being then compared with ANOVA and the Fisher Test (p <0.05).
Quercetin delayed 1.18 fold tumour appearance and increased 8.87 fold non-neoplastic body weight gain, whereas 5 caffeoylquinic acid did it in a lesser extent (1.17 and 2.48 fold, respectively), with tumour weight being consequent with the evolution time. Quercetin induced >1.15 fold tumour hydroperoxides and lipoperoxides, whereas 5 caffeoylquinic acid induced only lipoperoxides. Although both phytochemicals reduced <0.85 fold hydroperoxides and lipoperoxides in the kidney, only quercetin was also antioxidant in the liver. Additionally, 5 caffeoylquinic acid increased >1.15 fold hepatic and renal weights. Although these phytochemicals did not modify telencephalic interleukin 6 production, quercetin augmented 2.51 fold interleukin 6 in the diencephalon, whereas 5 caffeoylquinic acid decreased it 0.43 fold.
Quercetin delayed lung adenocarcinoma appearance and increased the non-neoplastic body weight gain in mice with tumour oxidative stress, without brain interleukin 6 participation. 5 caffeoylquinic acid showed similar effects, although they were weaker. Additionally, quercetin acted as a hepatic and renal antioxidant, whereas 5 caffeoylquinic acid only exerted this effect in the kidney. Therefore, safe oral doses of this flavonoid are promissory to modulate lung cancer progression, with further studies being encouraged.
肺腺癌（LAC）是全球主要的癌症死亡原因，它表现出高度侵袭性、功能下降、全身受损和严重恶病质，这些可能会被饮食中的氧化还原活性植物化学物质所抵消。因此，我们的目的是确定口服槲皮素和 5-咖啡酰奎宁酸的抗癌作用。
携带 LAC-1 的雄性 Balb/c 小鼠接受槲皮素（0-25μg/kg/d）和 5-咖啡酰奎宁酸（0-120μg/kg/d）治疗三周，然后使用方差分析和 Fisher 检验比较不同的有机和生化变量（p<0.05）。
槲皮素延迟了肿瘤出现的时间 1.18 倍，并增加了非肿瘤体重增加 8.87 倍，而 5-咖啡酰奎宁酸的作用较小（分别为 1.17 和 2.48 倍），肿瘤重量与演变时间一致。槲皮素诱导肿瘤羟自由基和脂自由基增加 1.15 倍，而 5-咖啡酰奎宁酸仅诱导脂自由基增加。虽然这两种植物化学物质都降低了肾脏中羟自由基和脂自由基的水平，但只有槲皮素有抗氧化作用。此外，5-咖啡酰奎宁酸增加了肝和肾的重量。虽然这两种植物化学物质没有改变大脑中白细胞介素 6 的产生，但槲皮素增加了间脑的白细胞介素 6 2.51 倍，而 5-咖啡酰奎宁酸则降低了 0.43 倍。
槲皮素延迟了肺腺癌的出现，并增加了荷瘤小鼠的非肿瘤体重增加，同时增加了肿瘤的氧化应激，但没有参与大脑白细胞介素 6 的产生。5-咖啡酰奎宁酸也表现出类似的作用，尽管作用较弱。此外，槲皮素有肝和肾抗氧化作用，而 5-咖啡酰奎宁酸仅在肾脏中发挥这种作用。因此，口服这种类黄酮的安全剂量有望调节肺癌的进展，鼓励进一步研究。
