Development. 2020 Feb 21;147(4):dev188904. doi: 10.1242/dev.188904.
Cortical development involves a switch from the self-amplification of stem cells to the generation of neuron and glia by progenitors. A new paper in Development investigates the molecular control of mitosis in these two stages, using simultaneous labelling and gene knockout in clones in the developing mouse brain. We caught up the paper's two authors Caroline Johnson and her supervisor Troy Ghashghaei, Professor of Neurobiology at the College of Veterinary Medicine at North Carolina State University, to find out more.
皮质发育涉及从干细胞的自我扩增到祖细胞产生神经元和神经胶质的转变。发育杂志上的一篇新论文研究了这两个阶段有丝分裂的分子控制,使用了在发育中的小鼠大脑中的克隆中进行的同时标记和基因敲除。我们联系了该论文的两位作者卡罗琳·约翰逊(Caroline Johnson)和她的导师北卡罗来纳州立大学兽医学院的神经生物学教授特洛伊·加什盖(Troy Ghashghaei),以了解更多信息。