Development. 2020 Nov 23;147(22):dev197715. doi: 10.1242/dev.197715.
Hox genes instruct positional identity along the anterior-posterior axis of the animal body. A new paper in Development addresses the question of how similar Hox genes can define diverse cell fates, using mouse motor neurons as a model. To hear more about the work, we caught up with the paper's two first authors, PhD students Milica Bulajić and Divyanshi Srivastava, and their respective supervisors Esteban Mazzoni (Associate Professor of Biology at New York University, USA) and Shaun Mahony (Assistant Professor of Biochemistry & Molecular Biology at Penn State University, USA).
Hox 基因沿动物体的前后轴指示位置身份。发育领域的一篇新论文探讨了相似的 Hox 基因如何定义不同的细胞命运,以小鼠运动神经元为模型。为了更多地了解这项工作,我们采访了论文的两位第一作者博士研究生 Milica Bulajić 和 Divyanshi Srivastava ,以及他们各自的导师 Esteban Mazzoni(美国纽约大学生物学副教授)和 Shaun Mahony(美国宾夕法尼亚州立大学生物化学与分子生物学助理教授)。