Van de Bor M, Janssen J W, Van Bel F, Ruys J H
Department of Paediatrics, University Hospital, Leiden, The Netherlands.
Early Hum Dev. 1988 Aug-Sep;17(2-3):165-74. doi: 10.1016/0378-3782(88)90005-9.
Serum creatine kinase BB (CK-BB) determinations were performed daily in 49 newborn infants of less than 34 weeks gestation to evaluate its usefulness in predicting the occurrence of periventricular-intraventricular haemorrhage (PIVH). Using ultrasound PIVH was detected in 20 infants (41%); five grade I, seven grade II, two grade III, six grade IV (grading according to Papile et al.). Infants who developed severe PIVH (grade IV) during the study period had significantly higher serum CK-BB activities immediately after birth when compared with infants who developed less severe haemorrhages (grades I, II and II) or no PIVH. We postulate that these high serum enzyme activities are caused by perinatal brain cell damage which is an important antecedent of severe PIVH. Therefore, serum CK-BB activities at birth can be used as predictor of severe PIVH.
对49例孕周小于34周的新生儿每日进行血清肌酸激酶BB（CK-BB）测定，以评估其在预测脑室周围-脑室内出血（PIVH）发生方面的作用。通过超声检查，在20例婴儿（41%）中检测到PIVH；5例为I级，7例为II级，2例为III级，6例为IV级（根据Papile等人的分级）。与发生较轻出血（I级、II级和III级）或未发生PIVH的婴儿相比，在研究期间发生严重PIVH（IV级）的婴儿出生后即刻血清CK-BB活性显著更高。我们推测这些高血清酶活性是由围产期脑细胞损伤引起的，而围产期脑细胞损伤是严重PIVH的一个重要先兆。因此，出生时的血清CK-BB活性可作为严重PIVH的预测指标。
