Amato M, Hüppi P, Gambon R
Department of Pediatrics, Children's Hospital, Aarau, Switzerland.
Brain Dev. 1992 Jul;14(4):226-9. doi: 10.1016/s0387-7604(12)80234-8.
The association between measurements of lateral ventricle dilatation determined by serial ultrasound and brain specific creatine-kinase isoenzyme patterns (CK-BB) is studied in 60 very low birth weight preterm neonates of 1,500 g birth weight or 32 weeks gestation or less. The patients were divided into three groups according to cranial ultrasonographic findings: Group A (n = 20) had isolated peri-intraventricular hemorrhage (PIVH); group B (n = 20) had PIVH and dilated ventricles (VM); group C (n = 20) were normal matched preterms and formed the control group. Compared to control babies or those with isolated PIVH, high serum concentrations of CK-BB were observed after birth in babies with persistent dilated ventricles at two weeks postnatal age (p less than 0.01). No difference was found between CK-BB levels of babies with isolated PIVH and control group (p greater than 0.05). We suggest that an elevated CK-BB value is found in babies with persistent ventricular dilatation suggesting severe and diffuse brain damage after post-hemorrhagic ventriculomegaly (VM).
对60例出生体重1500克或胎龄32周及以下的极低出生体重早产儿，研究了通过系列超声测定的侧脑室扩张与脑特异性肌酸激酶同工酶模式（CK - BB）之间的关联。根据颅脑超声检查结果，将患者分为三组：A组（n = 20）有孤立性脑室周围脑室内出血（PIVH）；B组（n = 20）有PIVH和脑室扩张（VM）；C组（n = 20）为正常匹配的早产儿，作为对照组。与对照婴儿或孤立性PIVH婴儿相比，出生后两周时持续性脑室扩张婴儿的血清CK - BB浓度较高（p < 0.01）。孤立性PIVH婴儿与对照组的CK - BB水平无差异（p > 0.05）。我们认为，持续性脑室扩张的婴儿CK - BB值升高，提示出血后脑室扩大（VM）后存在严重弥漫性脑损伤。
