Shields W D, Feldman R C
J Pediatr. 1982 Mar;100(3):464-8. doi: 10.1016/s0022-3476(82)80461-7.
Periventricular hemorrhage in the preterm infant kills or injuries thousands annually. Because of the relatively recent emergencies of PVH as a major problem, the pathophysiology of this disorder is not yet known. This study was performed to examine the relationship between brain origin creatine kinase and the occurrence of PVH, both prior to the time of the hemorrhage and after. Twenty-six preterm infants were studied. Serum CK-BB levels were obtained at birth, if possible, and twice daily thereafter for four to seven days. The PVH was proven by either CT scan or autopsy. Infants with PVH had significantly higher average serum levels of CK-BB when compared to infants without, both immediately after birth and during the follow-up period.
早产儿脑室周围出血每年导致数千人死亡或受伤。由于脑室周围出血作为一个主要问题是相对较新出现的紧急情况，这种病症的病理生理学尚不清楚。本研究旨在检查脑源性肌酸激酶与脑室周围出血发生之间在出血前和出血后的关系。对26名早产儿进行了研究。如果可能，在出生时获取血清CK-BB水平，此后每天两次，持续四至七天。通过CT扫描或尸检证实脑室周围出血。与未发生脑室周围出血的婴儿相比，发生脑室周围出血的婴儿在出生后即刻及随访期间血清CK-BB的平均水平显著更高。
