College of Medicine, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan City, Taiwan.
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
J Pathol. 2020 Apr;250(5):656-666. doi: 10.1002/path.5404. Epub 2020 Mar 14.
The cells of the mononuclear phagocyte system (MPS) constitute a dispersed organ, which is distributed throughout the body. Macrophages in different tissues display distinctive mosaic phenotypes as resident and recruited cells of embryonic and bone marrow origin, respectively. They help to maintain homeostasis during development and throughout adult life, yet contribute to the pathogenesis of many disease processes, including inflammation, innate and adaptive immunity, metabolic disorders, and cancer. Heterogeneous tissue macrophage populations display a wide variety of surface molecules to recognise and respond to host, microbial, and exogenous ligands in their environment; their receptors mediate the uptake and destruction of effete and dying host cells and pathogens, as well as contribute trophic and secretory functions within every organ in the body. Apart from local cellular interactions, macrophage surface molecules and products serve to mobilise and coordinate systemic humoral and cellular responses. Their use as antigen markers in pathogenesis and as potential drug targets has lagged in clinical pathology and human immunotherapy. In this review, we summarise the properties of selected surface molecules expressed on macrophages in different tissues and disease processes, to provide a functional basis for diagnosis, further research, and treatment. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
单核吞噬细胞系统 (MPS) 的细胞构成了一个分散的器官，分布在全身。不同组织中的巨噬细胞分别作为胚胎和骨髓来源的常驻和募集细胞表现出独特的镶嵌表型。它们有助于在发育过程中和整个成年期维持内环境稳定，但也导致许多疾病过程的发病机制，包括炎症、先天和适应性免疫、代谢紊乱和癌症。异质性组织巨噬细胞群体显示出广泛的表面分子，以识别和响应其环境中的宿主、微生物和外源性配体；它们的受体介导对衰老和垂死的宿主细胞和病原体的摄取和破坏，以及在体内每个器官中发挥营养和分泌功能。除了局部细胞相互作用外，巨噬细胞表面分子和产物还可用于动员和协调全身体液和细胞反应。它们在发病机制中的抗原标记物特性和作为潜在的药物靶点在临床病理学和人类免疫治疗中的应用滞后。在这篇综述中，我们总结了不同组织和疾病过程中巨噬细胞表面分子的特性，为诊断、进一步研究和治疗提供了功能基础。© 2020 英国和爱尔兰病理学学会。由 John Wiley & Sons, Ltd 出版。
