Jiang Jinyuan, Liu Jidan, Yang Zhenke, Zheng Jieying, Tian Xin, Zheng Liyao, Liu Zhao-Qing
School of Chemistry and Chemical Engineering/Institute of Clean Energy and Materials/Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou, 510006, P. R. China.
Org Biomol Chem. 2022 Jan 5;20(2):339-344. doi: 10.1039/d1ob02305e.
An efficient rhodium(III)-catalyzed direct C-H oxidative annulation of isoquinolones with allyl alcohols as C1 synthons has been successfully developed. This protocol enables the straightforward synthesis of structurally diverse isoindolo[2,1-]isoquinolin-5(7)-ones with high atom economy, tolerates a broad spectrum of functionalities, and is applicable to one-pot operation from readily available -methoxybenzamides.
已成功开发出一种高效的铑（III）催化的异喹诺酮与烯丙醇作为C1合成子的直接C-H氧化环化反应。该方法能够以高原子经济性直接合成结构多样的异吲哚并[2,1-]异喹啉-5（7）-酮，耐受多种官能团，并且适用于从容易获得的邻甲氧基苯甲酰胺进行一锅法操作。
