Wu X M, Feng Y J, Zeng C R, Wang M J
Department of Otorhinolaryngology Head and Neck Surgery，the Second Affiliated Hospital of Hainan Medical College，Haikou，570000，China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jan;34(1):60-63. doi: 10.13201/j.issn.1001-1781.2020.01.015.
To investigate the clinical effect and safety of nasal spray allergen blocker combined with antihistamines in children with allergic rhinitis. Eighty-four children with mild-severe allergic rhinitis were randomly divided into observation group（42 cases） and control group（42 cases）. Children in control group were treated with azelastine hydrochloride nasal spray, while children in observation group added with nasal spray allergen blocker on the basis of control group. Both groups were treated for 4 weeks. The changes of symptoms and signs integral in both groups were compared and analyzed after 1, 2 and 4 weeks treatment. And Clinical efficacy and adverse reactions between two groups were compared after treatment. Among 4 weeks treatment, the symptoms and signs integral of the two groups showed a significant decreasing trend（<0.01）. The reduction in the observation group was greater than that in the control group, there were statistical differences in the variation trends of symptoms and signs integral between the two groups（<0.01, <0.05）. And there were significant differences in symptoms and signs integral between the two groups（<0.05）. The total effective rate of observation group（90.5%） was significantly higher than that of control group（64.3%）（<0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups（9.5%vs 4.8%, >0.05）. The effect of nasal spray allergen blocker combined with antihistamines on allergic rhinitis children is remarkable. They can alleviate the symptoms and signs of allergic rhinitis with rapidity and safety.
探讨鼻用过敏原阻断剂联合抗组胺药治疗儿童过敏性鼻炎的临床疗效及安全性。将84例轻 - 重度过敏性鼻炎患儿随机分为观察组（42例）和对照组（42例）。对照组患儿采用盐酸氮卓斯汀鼻喷雾剂治疗，观察组患儿在对照组基础上加用鼻用过敏原阻断剂。两组均治疗4周。比较分析两组治疗1、2、4周后症状和体征积分的变化情况。并比较治疗后两组的临床疗效及不良反应。在4周治疗期间，两组症状和体征积分均呈显著下降趋势（<0.01）。观察组下降幅度大于对照组，两组症状和体征积分变化趋势有统计学差异（<0.01，<0.05）。且两组症状和体征积分有显著差异（<0.05）。观察组总有效率（90.5%）显著高于对照组（64.3%）（<0.05）。两组不良反应发生率无统计学差异（9.5% vs 4.8%，>0.05）。鼻用过敏原阻断剂联合抗组胺药治疗过敏性鼻炎患儿效果显著。可快速、安全地缓解过敏性鼻炎的症状和体征。
