Wright J L, Tron V, Wiggs B, Churg A
Department of Pathology, University of British Columbia, Vancouver, Canada.
Exp Lung Res. 1988;14(4):537-48. doi: 10.3109/01902148809087826.
It has been suggested that exposure to both asbestos and cigarette smoke can produce worse parenchymal lung disease than exposure to asbestos alone. Using a guinea pig model of asbestos administration that produces primarily airway disease and associated airflow abnormalities, we showed previously that the combination of asbestos and smoke acts synergistically to produce more marked increases in tissue collagen, fibrosis of airway walls, and early interstitial fibrosis than are seen with asbestos alone. To investigate the functional effects of these morphological and biochemical abnormalities, pulmonary function tests for volumes and flows, including lung volumes, pressure-volume curves, and flow-volume curves, were performed. By themselves, both smoke and asbestos produced increases in total lung capacity (TLC), residual volume (RV), and functional residual capacity (FRC); the two agents together made all these changes worse than either one alone. Both smoking and asbestos moved the pressure-volume curve upward, and the effects of the two agents together were again greater than either alone. Similarly, both smoke and asbestos decreased flows, and the two agents produced more severe impairment than either one by itself. The changes in volumes, pressure-volume curve, and flows correlated with both increased thickness of small airway walls and increases in airspace size. These observations indicate that, at least in this guinea pig model, cigarette smoke can potentiate the functional consequences of asbestos exposure.
有人提出，同时接触石棉和香烟烟雾比仅接触石棉会导致更严重的实质性肺部疾病。我们使用一种主要导致气道疾病和相关气流异常的石棉给药豚鼠模型，先前已表明，与单独接触石棉相比，石棉和烟雾的组合具有协同作用，会使组织胶原蛋白增加更显著、气道壁纤维化以及早期间质纤维化更明显。为了研究这些形态学和生化异常的功能影响，我们进行了肺功能测试，包括肺容积、压力 - 容积曲线和流量 - 容积曲线等容积和流量方面的测试。单独来看，烟雾和石棉都会使肺总量（TLC）、残气量（RV）和功能残气量（FRC）增加；两者共同作用会使所有这些变化比单独一种物质更严重。吸烟和石棉都会使压力 - 容积曲线向上移动，且两者共同作用的效果再次大于单独任何一种物质。同样，烟雾和石棉都会降低气流，且两者共同作用导致的损害比单独任何一种物质都更严重。容积、压力 - 容积曲线和气流的变化与小气道壁厚度增加和肺泡腔大小增加相关。这些观察结果表明，至少在这个豚鼠模型中，香烟烟雾会增强石棉暴露的功能后果。
