Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, Italy.
Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Allergy Unit, University of Messina, Messina, Italy.
Diabetes Res Clin Pract. 2020 Apr;162:108089. doi: 10.1016/j.diabres.2020.108089. Epub 2020 Feb 19.
Aim of our observational study was to assess the prevalence of allergic contact dermatitis among children and adolescents with type 1 diabetes who use technological devices for diabetes treatment and its management. Secondary outcome was to identify possible clinical and/or demographic variables that could be associated to contact dermatitis.
Among a total of 215 patients using insulin pumps and/or glucose sensors followed-up at our Pediatric Diabetes Centre between January and September 2018, 64 patients were enrolled and 42 (19 male and 23 female) completed the study. Demographic and clinical features of the study population were statistically analysed. All the patients underwent patch testing with specific allergens belonged to resin and acrylate classes.
Eighteen patients experienced skin reactions suggestive of allergic contact dermatitis, demonstrating a prevalence of 8.4%. None of the demographic or clinical variables were associated to skin reactions. Colophonium was the most identified sensitizing allergen (87.5% of the cases).
The rate of sensitization to allergens included into diabetes devices among pediatric patients is higher than commonly assumed. Well-designed studies are needed to better investigate the association between type 1 diabetes and allergic contact dermatitis. Moreover, we suggest that manufactures should supply detailed information about adhesives in order to avoid dermatological complications and consequently a worsening of disease management and patients' quality of life.
本观察性研究旨在评估使用糖尿病治疗和管理技术设备的 1 型糖尿病儿童和青少年中过敏性接触性皮炎的患病率。次要结局是确定可能与接触性皮炎相关的临床和/或人口统计学变量。
在 2018 年 1 月至 9 月期间在我们的儿科糖尿病中心接受胰岛素泵和/或葡萄糖传感器治疗的 215 名患者中，共有 64 名患者入组，其中 42 名（19 名男性和 23 名女性）完成了研究。对研究人群的人口统计学和临床特征进行了统计学分析。所有患者均接受了特定过敏原的斑贴试验，这些过敏原属于树脂和丙烯酸盐类。
18 名患者出现了疑似过敏性接触性皮炎的皮肤反应，患病率为 8.4%。没有任何人口统计学或临床变量与皮肤反应相关。松香是最常见的致敏过敏原（占病例的 87.5%）。
在儿科患者中，对糖尿病设备中包含的过敏原的致敏率高于通常认为的水平。需要进行精心设计的研究，以更好地调查 1 型糖尿病与过敏性接触性皮炎之间的关系。此外，我们建议制造商应提供有关粘合剂的详细信息，以避免皮肤并发症，从而改善疾病管理和患者的生活质量。
