Jarman A P, Higgs D R
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
EMBO J. 1988 Nov;7(11):3337-44. doi: 10.1002/j.1460-2075.1988.tb03205.x.
In an analysis of a 90-kb region around the human beta-globin gene complex we have identified at least eight sites of attachment to the nuclear scaffold (SARs). While these have many potential functions, there appears to be a particular association with sequences important in the regulation of the complex. Two SARs are close to the known enhancer-like elements of the beta-globin gene. SARs flanking the complex co-habit with the boundaries of the putative beta-like globin gene regulatory domain. In contrast, we have detected no SARs within a 140-kb region of the human alpha-globin gene complex. If SARs play a role in the regulation of gene expression then this structural difference would imply a difference in the regulation of the two complexes.
在对人类β-珠蛋白基因复合体周围90千碱基区域的分析中，我们鉴定出了至少八个与核骨架附着的位点（SARs）。虽然这些位点具有许多潜在功能，但似乎与该复合体调控中重要的序列存在特定关联。两个SARs靠近β-珠蛋白基因已知的增强子样元件。复合体两侧的SARs与假定的β样珠蛋白基因调控域的边界共同存在。相比之下，我们在人类α-珠蛋白基因复合体的140千碱基区域内未检测到SARs。如果SARs在基因表达调控中起作用，那么这种结构差异将意味着两个复合体在调控上存在差异。
