UCSF, United States.
UCSF, United States.
Curr Opin Insect Sci. 2020 Feb;37:39-48. doi: 10.1016/j.cois.2019.11.005. Epub 2020 Jan 30.
The follicle stem cell (FSC) lineage in the Drosophila ovary is a highly informative model of in vivo epithelial stem cell biology. Studies over the past 30 years have identified roles for every major signaling pathway in the early FSC lineage. These pathways regulate a wide variety of cell behaviors, including self-renewal, proliferation, survival and differentiation. Studies of cell signaling in the follicle epithelium have provided new insights into how these cell behaviors are coordinated within an epithelial stem cell lineage and how signaling pathways interact with each other in the native, in vivo context of a living tissue. Here, we review these studies, with a particular focus on how these pathways specify differences between the FSCs and their daughter cells. We also describe common themes that have emerged from these studies, and highlight new research directions that have been made possible by the detailed understanding of the follicle epithelium.
果蝇卵巢中的卵泡干细胞 (FSC) 谱系是体内上皮干细胞生物学的一个非常有意义的模型。在过去的 30 年中，研究已经确定了早期 FSC 谱系中每个主要信号通路的作用。这些途径调节了各种各样的细胞行为，包括自我更新、增殖、存活和分化。对卵泡上皮细胞信号转导的研究为这些细胞行为如何在一个上皮干细胞谱系内协调以及信号通路如何在一个活体组织的天然、体内环境中相互作用提供了新的见解。在这里，我们回顾了这些研究，特别关注这些途径如何在 FSCs 和它们的子细胞之间指定差异。我们还描述了这些研究中出现的共同主题，并强调了通过对卵泡上皮的详细了解而成为可能的新的研究方向。
