Departments of Radiology, Stony Brook Medicine, 101 Nicolls Rd, Stony Brook, New York, 11794, USA.
Departments of Neurology, Stony Brook Medicine, 101 Nicolls Rd, Stony Brook, New York, 11794, USA.
Mult Scler Relat Disord. 2020 Jun;41:101985. doi: 10.1016/j.msard.2020.101985. Epub 2020 Feb 6.
Clinically isolated syndrome (CIS) is a central nervous system inflammatory and demyelinating event that lasts at least 24 h and can represent the first episode of relapsing-remitting multiple sclerosis. MRI is an important imaging tool in the diagnosis and longitudinal monitoring of CIS progression. Accurate differential diagnosis of high-risk versus low-risk CIS is important because high-risk CIS patients could be treated early. Although a few studies have previously characterized CIS and explored possible imaging predictors of CIS conversion to MS, it remains unclear which amongst the commonly measured MRI features, if any, are good predictors of rapid disease progression in CIS patients. The goal of this review paper is to identify MRI features in high-risk CIS patients that are associated with rapid disease activity within 5 years as measured by clinical disability.
临床孤立综合征（CIS）是一种中枢神经系统炎症和脱髓鞘事件，持续至少 24 小时，可代表复发缓解型多发性硬化症的首次发作。MRI 是诊断和纵向监测 CIS 进展的重要影像学工具。准确鉴别高危 CIS 与低危 CIS 非常重要，因为高危 CIS 患者可以早期接受治疗。尽管之前有一些研究对 CIS 进行了特征描述，并探讨了 CIS 转化为 MS 的可能影像学预测因素，但仍不清楚在 CIS 患者中，哪些常见的 MRI 特征（如果有的话）是疾病快速进展的良好预测因素。本综述的目的是确定与临床残疾评估的 5 年内疾病活动快速进展相关的高危 CIS 患者的 MRI 特征。
