School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China.
School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China.
Int J Biol Macromol. 2020 Jun 1;152:199-206. doi: 10.1016/j.ijbiomac.2020.02.214. Epub 2020 Feb 20.
Hyaluronic acid (HA) is a major glycosaminoglycan, a family of structurally complex, linear, anionic hetero-co-polysaccharides. HA is important in various anatomical structures including the eyes, joints, heart and myriad intricate tissues, and is currently widely used in the therapeutics and cosmetics areas. The synthesis of HA of well-defined and uniform chain lengths is of major interest for the development of safer and more reliable drugs and to gain a better understanding of its structure-activity relationships. However, HA has received less attention from the synthetic carbohydrate community compared with other members of the glycosaminoglycan family. In this review, we examine the remarkable progress that has been made in the chemical and chemoenzymatic synthesis of HA, providing a broad spectrum of options to access HA of well controlled chain lengths.
透明质酸（HA）是一种主要的糖胺聚糖，是结构复杂、线性、阴离子异质共多糖家族的一员。HA 存在于多种解剖结构中，包括眼睛、关节、心脏和无数复杂的组织，目前在治疗学和化妆品领域得到广泛应用。具有明确和均匀链长的 HA 的合成对于开发更安全、更可靠的药物以及更好地了解其结构-活性关系具有重要意义。然而，与糖胺聚糖家族的其他成员相比，HA 受到合成碳水化合物领域的关注较少。在这篇综述中，我们考察了在 HA 的化学和化学酶法合成方面取得的显著进展，为获得具有良好控制链长的 HA 提供了广泛的选择。
