UCP1 多态性与 2 型糖尿病的关联及其与体力活动和久坐行为的相互作用。

Association of UCP1 polymorphisms with type 2 diabetes mellitus and their interaction with physical activity and sedentary behavior.

机构信息

School of Public Health, Guangxi Medical University, Nanning 530021, People's Republic of China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, People's Republic of China.

Third Affiliated Hospital of Guangxi Medical University, Nanning 530021, People's Republic of China.

出版信息

Gene. 2020 May 20;739:144497. doi: 10.1016/j.gene.2020.144497. Epub 2020 Feb 20.

DOI:10.1016/j.gene.2020.144497

PMID:32088243

Abstract

BACKGROUND

Uncoupling protein 1 (UCP1) has been reported to be associated with type 2 diabetes mellitus (T2DM) in different populations, however, little is reported in Chinese population. The present study aimed to explore the association between some polymorphisms of UCP1 with T2DM and the interactions between UCP1 and physical activity/sedentary behavior (PA/SB) lifestyle in Chinese population.

METHODS

Three polymorphisms (rs1472268, rs3811790 and rs3811791) were genotyped in 929 T2DM patients and 1044 nondiabetic controls. The data of PA and SB were acquired. Logistic regression and linear regression were conducted to assess the association of UCP1 and T2DM and related traits.

RESULTS

The CC genotype of rs3811791 was significantly associated with an increased risk of T2DM [odds ratio (OR) = 1.42, P = 0.042] and a higher level of triglyceride (TG) (β = 0.048, P = 0.034). This association still existed in the group of SB ≥ 3 h/d (OR = 1.66, P = 0.009) and the group of PA ≥ 150 min/week and SB ≥ 3 h/d (OR = 1.60, P = 0.034). In the group of PA < 150 min/week and SB < 3h/d, CC genotype was associated with a higher level of homeostatic model assessment of insulin resistance (HOMA-IR) index, and in the group of PA < 150 min/week and SB ≥ 3 h/d, CC genotype was associated with increased level of TG and decreased high-density lipoprotein cholesterol (HDL-C).

CONCLUSION

This study suggests that rs3811791 of UCP1 may be associated with T2DM and TG. Moreover, we demonstrate that SB interacted with rs3811791 of UCP1 was associated with T2DM, and PA interacted with rs3811791 of UCP1 was associated with the level of HOMA-IR, HDL-C, and TG.

摘要

背景

解偶联蛋白 1（UCP1）已被报道与不同人群的 2 型糖尿病（T2DM）相关，但在中国人群中的报道较少。本研究旨在探讨 UCP1 的一些多态性与 T2DM 的关系，以及 UCP1 与中国人群体力活动/久坐行为（PA/SB）生活方式之间的相互作用。

方法

在 929 例 T2DM 患者和 1044 名非糖尿病对照中，对三个多态性（rs1472268、rs3811790 和 rs3811791）进行基因分型。获取 PA 和 SB 的数据。采用 logistic 回归和线性回归评估 UCP1 与 T2DM 及相关表型的关系。

结果

rs3811791 的 CC 基因型与 T2DM 的发病风险增加显著相关[比值比（OR）=1.42，P=0.042]，且甘油三酯（TG）水平升高（β=0.048，P=0.034）。这种关联在 SB≥3h/d 的组（OR=1.66，P=0.009）和 PA≥150min/周且 SB≥3h/d 的组（OR=1.60，P=0.034）中仍然存在。在 PA<150min/周且 SB<3h/d 的组中，CC 基因型与更高的稳态模型评估胰岛素抵抗（HOMA-IR）指数相关，在 PA<150min/周且 SB≥3h/d 的组中，CC 基因型与 TG 水平升高和高密度脂蛋白胆固醇（HDL-C）水平降低相关。