Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt; Online Research Club (www.onlineresearchclub.org), Japan.
Online Research Club (www.onlineresearchclub.org), Japan; Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Gen Hosp Psychiatry. 2020 May-Jun;64:33-40. doi: 10.1016/j.genhosppsych.2020.02.001. Epub 2020 Feb 13.
There is preliminary evidence for lavender as an anxiolytic agent through various routes of administration. Our goal is to elucidate the best route of administration for lavender as a treatment for anxiety.
Thirteen electronic search engines were systematically scanned for relevant publications. The relevant articles were included after the title and abstract screening followed by the full-text screening. This study included randomized control trials reporting lavender for the treatment of anxiety. The protocol was registered in PROSPERO (CRD42017076711). Frequentist network meta-analysis and Bayesian meta-regression were conducted to report the best treatment modality and the effect of covariates on the effectiveness as an anxiolytic. Treatment arms were ordered according P-scores, where higher P-score indicates better treatment choice.
Forty studies were eligible for qualitative analysis, and 32 were included in quantitative analysis. Lavender aromatherapy was the best approach for the treatment of anxiety among other lavender modalities at the first week recording [Standardized Mean Difference (SMD) = -0.57, 95% CI (-1.14-0.01), P-score = 0.72], in addition to achieve at the first time points [SMD = -0, 95% CI (-0.97 ̶ -0.16), P-score = 0.69], compared to placebo; however, lavender massage along with foot bath were found to be the most efficacious for anxiety treatment at the study endpoint [SMD = -1.10, 95% CI = (-7.41 ̶ 5.21), P-score = 0.65]. Furthermore, network meta-regression revealed that the duration of therapy influenced treatment, suggesting Silexan (oral lavender) 80 mg (first rank probability = .116) as the favorable option for anxiety in long-term treatment.
Lavender aromatherapy is, clinically, superior in short-duration, while Silexan (oral lavender) 80 mg is preferable for long-term treatment of anxiety.
薰衣草通过各种给药途径作为抗焦虑药物已有初步证据。我们的目标是阐明薰衣草作为治疗焦虑症的最佳给药途径。
系统扫描了 13 个电子搜索引擎以查找相关出版物。经过标题和摘要筛选以及全文筛选后，将相关文章纳入研究。本研究纳入了报告薰衣草治疗焦虑症的随机对照试验。该方案已在 PROSPERO（CRD42017076711）中注册。进行了频率网络荟萃分析和贝叶斯荟萃回归，以报告最佳治疗方式以及协变量对作为抗焦虑药的有效性的影响。治疗臂根据 P 评分进行排序，其中较高的 P 评分表示更好的治疗选择。
有 40 项研究适合进行定性分析，有 32 项研究纳入定量分析。与其他薰衣草治疗方式相比，薰衣草芳香疗法在治疗焦虑症方面是最佳选择，在第 1 周记录时效果最佳 [标准化均数差（SMD）=-0.57，95%CI（-1.14-0.01），P 评分=0.72]，此外，与安慰剂相比，在首次测量时也达到了效果 [SMD=-0，95%CI（-0.97 ̶ -0.16），P 评分=0.69]；然而，薰衣草按摩加足浴被发现是治疗焦虑症的最有效方法，在研究终点时效果最佳 [SMD=-1.10，95%CI（-7.41 ̶ 5.21），P 评分=0.65]。此外，网络荟萃回归显示治疗持续时间影响治疗效果，提示 Silexan（口服薰衣草）80mg（首选概率=0.116）是治疗焦虑症的首选药物。
薰衣草芳香疗法在短期治疗中具有临床优势，而 Silexan（口服薰衣草）80mg 则更适合长期治疗焦虑症。
