一种测定 L-α-甘油磷酸胆碱（L-α-GPC）对映体纯度的有效方法。
An effective method for the determination of the enantio-purity of L-α-glycerophosphocholine (L-α-GPC).
机构信息
Chemi SpA, Via Vadisi, 5 03010, FR, Italy.
Dipartimento Di Chimica e Biologia "A. Zambelli", Università degli studi di Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy.
出版信息
J Pharm Biomed Anal. 2020 May 10;183:113152. doi: 10.1016/j.jpba.2020.113152. Epub 2020 Feb 8.
Herein we describe for the first time a practical analytical method for determining the enantio-purity of L-α-glycerophosphocholine (L-α-GPC) by chiral derivatization. The use of a suitable chiral boronic acid allowed the formation of a mixture of two diastereomeric boronate esters whose ratio, carefully analyzed by HNMR spectroscopy, reflects L-α-GPC enantiomeric excesses. The determination of the enantiopurity of L-α-GPC furnishes convincing correlations with its manufacturing process.
在此，我们首次描述了一种实用的分析方法，通过手性衍生化来测定 L-α-甘油磷酸胆碱（L-α-GPC）的对映体纯度。使用合适的手性硼酸可以形成两种非对映异构体硼酸酯的混合物，通过 1H NMR 光谱仔细分析其比例可以反映 L-α-GPC 的对映体过量。L-α-GPC 对映体纯度的测定与其制造工艺有很好的相关性。
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