School of Food Science and Engineering, South China University of Technology, Wushan Road, Guangzhou, 510641, China.
South China Institute of Collaborative Innovation, Xincheng Road, Dongguan, 523808, China.
World J Microbiol Biotechnol. 2020 Feb 22;36(3):35. doi: 10.1007/s11274-020-02814-5.
Odd-chain fatty acids (OCFAs) naturally occur in bacteria, higher animals, and in plants. During recent years, they have received increasing attention due to their unique pharmacological properties and usefulness for agricultural and industrial applications. Recently, OCFAs have been identified and quantified in a few organisms, and new pharmacological functions of OCFAs have been reported. Some of the publications are related to the optimization of OCFA production through fermentation and genetic engineering. The present review aims to provide a summary on the recent progress in the field of microbial-derived OCFAs. More specifically, we outline the publications of OCFAs related to (i) different sources of OCFAs; (ii) endogenous synthesis of OCFAs; (iii) production of OCFAs through fermentation; (iv) genetic engineering related to OCFA; and (v) role of OCFAs in human health and disease. Finally, some areas that require further research are discussed.
奇数链脂肪酸（OCFAs）天然存在于细菌、高等动物和植物中。近年来，由于其独特的药理学特性和在农业和工业应用中的有用性，它们受到了越来越多的关注。最近，已经在一些生物体中鉴定和定量了 OCFAs，并且报道了 OCFAs 的新的药理学功能。一些出版物涉及通过发酵和遗传工程优化 OCFA 的生产。本综述旨在提供微生物衍生 OCFAs 领域的最新进展概述。更具体地说，我们概述了与以下方面相关的 OCFAs 的出版物：（i）OCFAs 的不同来源；（ii）OCFAs 的内源性合成；（iii）通过发酵生产 OCFAs；（iv）与 OCFA 相关的遗传工程；以及（v）OCFAs 在人类健康和疾病中的作用。最后，讨论了一些需要进一步研究的领域。
