Faculty of Medical Sciences, The University of the West Indies, West Indies.
Department of Surgery and Department of Physiology-Pharmacology, Wake Forest University, USA.
J Renin Angiotensin Aldosterone Syst. 2020 Jan-Mar;21(1):1470320320908186. doi: 10.1177/1470320320908186.
Low plasma renin activity hypertension is prevalent in Afro-Caribbean persons. Reduced angiotensin converting enzyme 2 activity from the counter angiotensin converting enzyme 2 /angiotensin-(1-7)/Mas receptor axis of the renin angiotensin aldosterone system has been reported in people with pre-hypertension, type 2 diabetes mellitus and chronic renal disease. This study investigates whether an imbalance in the regulatory mechanisms between the pressor arm of the renin angiotensin aldosterone system (angiotensin converting enzyme/angiotensin II/AT1 receptor) and the depressor axis (angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor) predisposes persons of African descent to hypertension.
In total, 30 normotensives and 30 recently diagnosed hypertensives aged 18-55 of Afro-Caribbean origin who are naïve to antihypertensive treatment will be recruited from public sector polyclinics in Barbados. Demographic and anthropometric data, clinical blood pressure readings, 24-hour urine collections and venous blood samples will be collected. Biological samples will be analysed for renin angiotensin aldosterone system peptide markers using radioimmunoassay.
We describe the design, methods and rationale for the characterization of renin angiotensin aldosterone system mechanisms that may contribute to hypertension predisposition in persons of African descent. Our findings will characterize any imbalance in the counter axes of the renin angiotensin aldosterone system in hypertensive Afro-Caribbeans with a potential view of identifying novel approaches with the use of renin angiotensin aldosterone system and mineralocorticoid blockers to manage the condition.
低血浆肾素活性高血压在非裔加勒比人群中较为普遍。有研究报道，在高血压前期、2 型糖尿病和慢性肾病患者中，肾素血管紧张素醛固酮系统的反向血管紧张素转换酶 2/血管紧张素-(1-7)/Mas 受体轴的血管紧张素转换酶 2 活性降低。本研究旨在探讨肾素血管紧张素醛固酮系统（血管紧张素转换酶/血管紧张素 II/AT1 受体）升压臂和降压轴（血管紧张素转换酶 2/血管紧张素-(1-7)/Mas 受体）之间的调节机制失衡是否使非裔人群易患高血压。
总共将招募 30 名年龄在 18-55 岁之间的、来自巴巴多斯公共部门诊所的、初诊为高血压的、非裔加勒比裔的、未接受过降压治疗的原发性高血压患者和 30 名血压正常的对照者。将收集人口统计学和人体测量学数据、临床血压读数、24 小时尿液采集和静脉血样。使用放射免疫分析法分析生物样本中的肾素血管紧张素醛固酮系统肽标志物。
我们描述了特征描述肾素血管紧张素醛固酮系统机制的设计、方法和原理，这些机制可能导致非裔人群易患高血压。我们的研究结果将描述高血压的非裔加勒比患者中肾素血管紧张素醛固酮系统反向轴的任何失衡情况，并可能确定使用肾素血管紧张素醛固酮系统和盐皮质激素受体阻滞剂来治疗该疾病的新方法。
