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富含血小板纤维蛋白在溶骨性腰椎滑脱椎间融合术中的应用。

The use of platelet-rich fibrin in lumbar interbody fusion in lytic spondylolisthesis.

作者信息

Boktor Joseph Gamal, Sultan Ahmed Maher, AlShahwani Awf, Barakat Ahmed Samir, Koptan Wael, Elmiligui Yasser

机构信息

Department of Orthopaedic Surgery, Al Haram Hospital, Giza, Egypt.

Department of Orthopaedic Surgery, Royal Gwent Hospital, Newport, United Kingdom.

出版信息

J Craniovertebr Junction Spine. 2019 Oct-Dec;10(4):234-239. doi: 10.4103/jcvjs.JCVJS_97_19. Epub 2020 Jan 23.

DOI:10.4103/jcvjs.JCVJS_97_19
PMID:32089617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7008658/
Abstract

STUDY DESIGN

This was a retrospective observational study.

AIM

The aim of this study was to evaluate the effectiveness of applying the platelet-rich fibrin (PRF) with bone graft in accelerating the rate of lumbar interbody fusion.

SETTINGS AND DESIGN

This was a retrospective study measuring the outcome of posterior lumbar interbody fusion (PLIF) combined with PRF versus PLIF alone in the management of lytic spondylolisthesis.

SUBJECTS AND METHODS

Forty patients were treated with instrumented PLIF for low-grade lytic spondylolisthesis and divided into two equal groups: one with addition of PRF to the bone graft and the other without. The minimum follow-up was 2 years. Clinical outcome was measured by the Oswestry Disability Index (ODI) and Visual Analogue Pain Scale (VAS) at 3, 6, and 12 months postoperatively. Radiological outcome was measured by standing X-ray at 3, 6, 12, and 24 months and computed tomography at 6 and 12 months postoperatively.

RESULTS

ODI for the PRF group improved by 60% and 79% at 6 and 12 months, respectively, whereas for the non-PRF group, it improved by 55% and 70%. Radiological outcome showed fusion in 15 of 20 cases in the PRF group (75%) by the 6 month and in 19 of 20 cases (95%) by 1 year and 100% at 2 years. In the control group, fusion was present in 12 of 20 cases (60%) by the 6 month and in 13 of 20 cases in the PRF group (65%) by 1 year and 90% at 2 years ( < 0.05).

CONCLUSIONS

These preliminary results show that PRF accelerates the rate of fusion in low-grade lytic spondylolisthesis in short-term follow-up.

摘要

研究设计

这是一项回顾性观察研究。

目的

本研究旨在评估应用富血小板纤维蛋白（PRF）与骨移植在加速腰椎椎间融合率方面的有效性。

设置与设计

这是一项回顾性研究，测量后路腰椎椎间融合术（PLIF）联合PRF与单纯PLIF治疗溶解性脊椎滑脱的结果。

研究对象与方法

40例低度溶解性脊椎滑脱患者接受器械辅助PLIF治疗，并分为两组，每组人数相等：一组在骨移植中添加PRF，另一组不添加。最短随访时间为2年。术后3、6和12个月通过Oswestry功能障碍指数（ODI）和视觉模拟疼痛量表（VAS）测量临床结果。术后3、6、12和24个月通过站立位X线片测量影像学结果，术后6和12个月通过计算机断层扫描测量。

结果

PRF组的ODI在6个月和12个月时分别改善了60%和79%，而非PRF组分别改善了55%和70%。影像学结果显示，PRF组20例中有15例（75%）在6个月时融合，19例（95%）在1年时融合，2年时100%融合。对照组20例中有12例（60%）在6个月时融合，13例（65%）在1年时融合，2年时90%融合（P<0.05）。

结论

这些初步结果表明，在短期随访中，PRF可加速低度溶解性脊椎滑脱的融合率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/87385a9511aa/JCVJS-10-234-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/7dd1c82b7073/JCVJS-10-234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/026f95178164/JCVJS-10-234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/369f56ebd1d6/JCVJS-10-234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/67770f6c053a/JCVJS-10-234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/aecd0fc4ce34/JCVJS-10-234-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/f9f372ce494c/JCVJS-10-234-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/87385a9511aa/JCVJS-10-234-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/7dd1c82b7073/JCVJS-10-234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/026f95178164/JCVJS-10-234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/369f56ebd1d6/JCVJS-10-234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/67770f6c053a/JCVJS-10-234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/aecd0fc4ce34/JCVJS-10-234-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/f9f372ce494c/JCVJS-10-234-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a89d/7008658/87385a9511aa/JCVJS-10-234-g007.jpg

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