Vaidya Mihir Mohan, Shenoy Asha Sharad, Goel Naina Atul
Department of Neuropathology, Seth GSMC, Mumbai, Maharashtra, India.
Department of Pathology, Seth GSMC, Mumbai, Maharashtra, India.
J Craniovertebr Junction Spine. 2019 Oct-Dec;10(4):250-253. doi: 10.4103/jcvjs.JCVJS_100_19. Epub 2020 Jan 23.
Chondrosarcomas of the spine are rare tumors and represent <10% of all chondrosarcomas. In the spine, they may arise from vertebral bodies or posterior elements. They may occur in patients ranging from 13 to 78 years of age. Here, we present a case of a 25-year-old female who presented with complaints of lower backache, stiffness in both lower limbs, and tingling sensation in the right lower limb. On examination, both power and sensations were decreased below waist. Magnetic resonance imaging spine revealed an extradural lesion at D5 vertebral body level with severe cord compression. We received the mass in multiple fragments which were grayish-white and firm to hard in consistency. Microscopically, a chondroid tumor was seen with cells arranged in lobules in abundant myxoid matrix. The neoplastic chondrocytes were large in size and had bizarre hyperchromatic nuclei. Few binucleate and multinucleate forms were also seen along with occasional atypical mitoses. There was permeation and destruction of the host bone, and the tumor was seen invading the marrow spaces. Few foci showed high cellularity. No osteoid formation was seen by the tumor. The tumor was diagnosed as Chondrosarcoma - Grade II.
脊柱软骨肉瘤是罕见肿瘤,占所有软骨肉瘤的比例不到10%。在脊柱中,它们可能起源于椎体或后部结构。患者年龄范围为13至78岁。在此,我们报告一例25岁女性病例,该患者主诉下背痛、双下肢僵硬以及右下肢有刺痛感。检查发现,腰部以下肌力和感觉均减退。脊柱磁共振成像显示在D5椎体水平有硬膜外病变,伴有严重脊髓受压。我们收到的肿物为多个碎块,呈灰白色,质地坚韧至坚硬。显微镜下可见一个软骨样肿瘤,细胞在丰富的黏液样基质中呈小叶状排列。肿瘤性软骨细胞体积大,细胞核怪异、深染。还可见少数双核和多核形式,以及偶尔的非典型有丝分裂。肿瘤有宿主骨的浸润和破坏,可见肿瘤侵犯骨髓腔。少数病灶细胞密集。肿瘤未见骨样形成。该肿瘤被诊断为二级软骨肉瘤。