Kim Mi-Jung, Cho Kyung-Ja, Ayala Alberto G, Ro Jae Y
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
Sarcoma. 2011;2011:405437. doi: 10.1155/2011/405437. Epub 2011 Feb 15.
Chondrosarcoma (CHS) is a malignant cartilage-forming tumor and usually occurs within the medullary canal of long bones and pelvic bones. Based on the morphologic feature alone, a correct diangosis of CHS may be difficult, Therefore, correlation of radiological and clinicopathological features is mandatory in the diagnosis of CHS. The prognosis of CHS is closely related to histologic grading, however, histologic grading may be subjective with high inter-observer variability. In this paper, we present histologic grading system and clinicopathological and radiological findings of conventional CHS. Subtypes of CHSs, such as dedifferentiated, mesenchymal, and clear cell CHSs are also presented. In addition, we introduce updated cytogenetic and molecular genetic findings to expand our understanding of CHS biology. New markers of cell differentiation, proliferation, and cell signaling might offer important therapeutic and prognostic information in near future.
软骨肉瘤（CHS）是一种恶性软骨形成性肿瘤，通常发生在长骨和骨盆的髓腔内。仅根据形态学特征，可能难以对CHS做出正确诊断。因此，在CHS的诊断中，放射学和临床病理特征的相关性是必不可少的。CHS的预后与组织学分级密切相关，然而，组织学分级可能具有主观性，观察者间差异较大。在本文中，我们介绍了传统CHS的组织学分级系统以及临床病理和放射学表现。还介绍了CHS的亚型，如去分化型、间充质型和透明细胞型CHS。此外，我们引入了最新的细胞遗传学和分子遗传学研究结果，以加深我们对CHS生物学的理解。细胞分化、增殖和细胞信号传导的新标志物可能在不久的将来提供重要的治疗和预后信息。
