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高糖通过上调和激活肿瘤坏死因子受体1加剧肿瘤坏死因子诱导的人牙周膜干细胞增殖抑制。

High Glucose Exacerbates TNF--Induced Proliferative Inhibition in Human Periodontal Ligament Stem Cells through Upregulation and Activation of TNF Receptor 1.

作者信息

Zhu Wenjun, Qiu Qihong, Luo Haoyuan, Zhang Fuping, Wu Juan, Zhu Xiaorui, Liang Min

机构信息

Department of Periodontology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.

Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China.

出版信息

Stem Cells Int. 2020 Feb 5;2020:4910767. doi: 10.1155/2020/4910767. eCollection 2020.

DOI:10.1155/2020/4910767
PMID:32089705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7025077/
Abstract

OBJECTIVE

This research is aimed at investigating how high glucose affects the proliferation and apoptosis in periodontal ligament stem cells (PDLSCs) in the presence of TNF-.

METHODS

PDLSCs obtained from periodontal healthy permanent teeth were treated under either high-glucose condition (30 mmol/L, G30 group) or normal glucose condition (5.6 mmol/L, G5.6 group) in the presence or absence of TNF-. . .

RESULTS

CCK-8 assay showed that high glucose exacerbated TNF-. . . . . .

CONCLUSION

High glucose exacerbates TNF--induced proliferative inhibition in human periodontal ligament stem cells through the upregulation and activation of TNF receptor 1. Inhibition of intracellular ROS expression by vitamin C partially rescues PDLSCs in terms of cell proliferation..

摘要

目的

本研究旨在探讨在存在肿瘤坏死因子-α（TNF-α）的情况下，高糖如何影响牙周膜干细胞（PDLSCs）的增殖和凋亡。

方法

从牙周健康恒牙获取的PDLSCs在存在或不存在TNF-α的情况下，于高糖条件（30 mmol/L，G30组）或正常糖条件（5.6 mmol/L，G5.6组）下进行处理。

结果

CCK-8检测显示高糖加剧了TNF-α……

结论

高糖通过上调和激活肿瘤坏死因子受体1加剧了TNF-α诱导的人牙周膜干细胞增殖抑制。维生素C对细胞内活性氧表达的抑制在细胞增殖方面部分挽救了PDLSCs。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/9b7d8fd748d2/SCI2020-4910767.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/1f542e6d6ae2/SCI2020-4910767.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/d216de918285/SCI2020-4910767.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/c0de195bdf8a/SCI2020-4910767.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/71b0f31097b6/SCI2020-4910767.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/8500c6e3d59c/SCI2020-4910767.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/e010d6fb27de/SCI2020-4910767.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/9b7d8fd748d2/SCI2020-4910767.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/1f542e6d6ae2/SCI2020-4910767.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/d216de918285/SCI2020-4910767.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/c0de195bdf8a/SCI2020-4910767.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/71b0f31097b6/SCI2020-4910767.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/8500c6e3d59c/SCI2020-4910767.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/e010d6fb27de/SCI2020-4910767.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55bb/7025077/9b7d8fd748d2/SCI2020-4910767.007.jpg

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