Hussein Nancy M S, Meade Josie L, Pandit Hemant, Jones Elena, El-Gendy Reem
Division of Oral Biology, School of Dentistry, University of Leeds, Leeds LS2 9JT, UK.
Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, Mansoura 35516, Egypt.
Bioengineering (Basel). 2021 Dec 3;8(12):202. doi: 10.3390/bioengineering8120202.
Periodontitis and diabetes mellitus (DM) are two of the most common and challenging health problems worldwide and they affect each other mutually and adversely. Current periodontal therapies have unpredictable outcome in diabetic patients. Periodontal tissue engineering is a challenging but promising approach that aims at restoring periodontal tissues using one or all of the following: stem cells, signalling molecules and scaffolds. Mesenchymal stem cells (MSCs) and insulin-like growth factor (IGF) represent ideal examples of stem cells and signalling molecules. This review outlines the most recent updates in characterizing MSCs isolated from diabetics to fully understand why diabetics are more prone to periodontitis that theoretically reflect the impaired regenerative capabilities of their native stem cells. This characterisation is of utmost importance to enhance autologous stem cells based tissue regeneration in diabetic patients using both MSCs and members of IGF axis.
牙周炎和糖尿病是全球范围内最常见且颇具挑战性的两种健康问题，它们相互影响且产生不利作用。目前的牙周治疗在糖尿病患者中效果难以预测。牙周组织工程是一种具有挑战性但前景广阔的方法，旨在通过使用以下一种或全部手段来修复牙周组织：干细胞、信号分子和支架。间充质干细胞（MSCs）和胰岛素样生长因子（IGF）分别是干细胞和信号分子的理想范例。本综述概述了从糖尿病患者中分离出的间充质干细胞特性的最新研究进展，以全面理解为何糖尿病患者更易患牙周炎，理论上这反映了其自身干细胞再生能力受损。这种特性描述对于利用间充质干细胞和胰岛素样生长因子轴成员增强糖尿病患者基于自体干细胞的组织再生至关重要。
