Daniali Seyede Shahrbanoo, Shayegh Sara, Tajaddin Mohammad Hasan, Goodarzi-Khoigani Masoomeh, Kelishadi Roya
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Science, Isfahan, Iran.
Student of Medical Science, Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
Int J Prev Med. 2020 Jan 24;11:3. doi: 10.4103/ijpvm.IJPVM_160_19. eCollection 2020.
In addition to its short-term effects, low birth weight increases the risk of noncommunicable diseases (NCDs) in adult life. The quality of maternal diet including the macronutrient intake is very important in this regard. This study aims to evaluate the possible associations between maternal zinc and neonatal anthropometric measures.
This cross-sectional study was conducted on 226 pairs of mothers-neonates in Isfahan, Iran. Maternal characteristics including the history of the disease, age, preconceptional weight, weight gain during pregnancy, as well as, anthropometric characteristics of neonates such as weight, height, length, and circumferences of head, belly, chest, and thigh were documented. Cord blood zinc was measured by atomic absorption spectrophotometer in three groups of neonates depending on their weights.
The gestational age of neonates was 35 to 38 weeks with a mean weight of 3.13 ± 0.42 kg. The mean of zinc concentration was 0.81 ± 0.18 and it was higher in neonates with appropriate weight than in those with high or low birth weight (0.82 ± 0.18, 0.75 ± 0.19, and 0.65 ± 0.12 ng/ml, respectively). Bivariate correlation analysis showed significant weak correlation between cord blood zinc and neonatal weight ( = 0.16, = 0.04).
The cord blood zinc concentration of normal-weight neonates was higher than others. Our findings suggest that maternal zinc may influence neonatal birth weight, and it should be considered in the primordial prevention of NCDs.
低出生体重除了会产生短期影响外，还会增加成年后患非传染性疾病（NCDs）的风险。在这方面，包括常量营养素摄入量在内的孕产妇饮食质量非常重要。本研究旨在评估孕产妇锌与新生儿人体测量指标之间可能存在的关联。
本横断面研究在伊朗伊斯法罕的226对母婴中进行。记录了孕产妇的特征，包括疾病史、年龄、孕前体重、孕期体重增加情况，以及新生儿的人体测量特征，如体重、身高、身长以及头围、腹围、胸围和大腿围。根据新生儿体重将其分为三组，用原子吸收分光光度计测量三组新生儿的脐带血锌含量。
新生儿的孕周为35至38周，平均体重为3.13±0.42千克。锌浓度的平均值为0.81±0.18，出生体重正常的新生儿的锌浓度高于出生体重高或低的新生儿（分别为0.82±0.18、0.75±0.19和0.65±0.12纳克/毫升）。双变量相关性分析显示脐带血锌与新生儿体重之间存在显著的弱相关性（r = 0.16，P = 0.04）。
正常体重新生儿的脐带血锌浓度高于其他新生儿。我们的研究结果表明，孕产妇锌可能会影响新生儿出生体重，在非传染性疾病的初级预防中应予以考虑。
