埃塞俄比亚西北部桑贾医院收治的发热且单感染或合并感染土壤传播蠕虫病患者的疟疾寄生虫血症
Malaria Parasitemia in Febrile Patients Mono- and Coinfected with Soil-Transmitted Helminthiasis Attending Sanja Hospital, Northwest Ethiopia.
作者信息
Getaneh Fantahun, Zeleke Ayalew Jejaw, Lemma Wossenseged, Tegegne Yalewayker
机构信息
Shegaw Mota Hospital, Ethiopia.
Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
出版信息
J Parasitol Res. 2020 Feb 4;2020:9891870. doi: 10.1155/2020/9891870. eCollection 2020.
BACKGROUND
Malaria is a life-threatening disease associated with high morbidity and mortality. Helminths are among the most widespread infectious agents prevalent in tropical and subtropical regions of the developing world. Malaria and soil-transmitted helminthiasis (STHs) are coendemic and major public health problems in Ethiopia. The effects of helminth coinfection on malaria parasitemia remained poorly understood. Therefore, the objective of this study was to assess malaria parasitemia among malaria-monoinfected and malaria-soil-transmitted helminthiasis-coinfected febrile patients attending Sanja Hospital, Northwest Ethiopia.
METHODS
A cross-sectional study with parallel groups was conducted to assess malaria parasitemia among malaria-monoinfected and malaria-soil-transmitted helminthiasis-coinfected febrile patients in Sanja Hospital from January to March 2019. Double population proportion formula was used for sample size calculation, and convenient sampling technique was used to select 134 study participants. Data were entered and analyzed by using the Statistical Package for Social Sciences (SPSS) version 20. Descriptive statistics, independent -test, and one-way analysis of variance (ANOVA) were performed. A value of <0.05 was considered as statistically significant.
RESULTS
From 134 malaria-positive study participants, 67 were malaria-monoinfected and 67 were malaria-STHs-coinfected patients. Out of 67 malaria STHs-coinfected patients, 54 (80.6%) were infected with hookworm followed by 11 (16.4%) and 2 (3%). The mean parasite density was significantly higher in malaria-STHs-coinfected patients than in patients infected with only parasite density was significantly higher in malaria-STHs-coinfected patients than in patients infected with only value of <0.05 was considered as statistically significant. parasite density was significantly higher in malaria-STHs-coinfected patients than in patients infected with only = 6.953, value of <0.05 was considered as statistically significant.
CONCLUSIONS
Infections with STHs, especially hookworm, were positively associated with parasite density. The current study finding also revealed that increased worm burden of hookworm as expressed by egg intensity had significantly increased parasite density. parasite density was significantly higher in malaria-STHs-coinfected patients than in patients infected with only parasite density was significantly higher in malaria-STHs-coinfected patients than in patients infected with only.
背景
疟疾是一种威胁生命的疾病，发病率和死亡率都很高。蠕虫是发展中世界热带和亚热带地区最普遍的感染源之一。疟疾和土壤传播的蠕虫病（STH）在埃塞俄比亚是共流行的，也是主要的公共卫生问题。蠕虫合并感染对疟疾寄生虫血症的影响仍知之甚少。因此，本研究的目的是评估在埃塞俄比亚西北部桑贾医院就诊的单纯感染疟疾和同时感染疟疾与土壤传播蠕虫病的发热患者中的疟疾寄生虫血症情况。
方法
2019年1月至3月，在桑贾医院进行了一项平行组横断面研究，以评估单纯感染疟疾和同时感染疟疾与土壤传播蠕虫病的发热患者中的疟疾寄生虫血症情况。采用双重总体比例公式计算样本量，并使用方便抽样技术选取134名研究参与者。数据使用社会科学统计软件包（SPSS）20版录入和分析。进行描述性统计、独立样本t检验和单因素方差分析（ANOVA）。P值<0.05被认为具有统计学意义。
结果
在134名疟疾阳性研究参与者中，67名是单纯感染疟疾的患者，67名是同时感染疟疾与土壤传播蠕虫病的患者。在67名同时感染疟疾与土壤传播蠕虫病的患者中，54名（80.6%）感染了钩虫，其次是11名（16.4%）感染蛔虫和2名（3%）感染鞭虫。同时感染疟疾与土壤传播蠕虫病的患者的平均疟原虫密度显著高于仅感染疟疾的患者（P<0.05被认为具有统计学意义）。同时感染疟疾与土壤传播蠕虫病的患者的疟原虫密度显著高于仅感染疟疾的患者（t = 6.953，P值<0.05被认为具有统计学意义）。
结论
土壤传播蠕虫的感染，尤其是钩虫感染，与疟原虫密度呈正相关。本研究结果还显示，以虫卵强度表示的钩虫蠕虫负担增加显著增加了疟原虫密度。同时感染疟疾与土壤传播蠕虫病的患者的疟原虫密度显著高于仅感染疟疾的患者。同时感染疟疾与土壤传播蠕虫病的患者的疟原虫密度显著高于仅感染疟疾的患者。
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