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维生素C对预防缺血-再灌注脑损伤的作用：大鼠实验研究

Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats.

作者信息

de Sales Kelston Paulo Felice, Pinto Bruno Araújo Serra, Ribeiro Nathalee Liberal Xavier, Melo Thamys Marinho, Galvão-Moreira Leonardo Victor, de Brito Filho Sebastião Barreto, Nigri Flávio

机构信息

Department of Vascular and Endovascular Surgery, University Hospital, Federal University of Maranhão, São Luís, Brazil.

Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, São Luís, Brazil.

出版信息

Int J Vasc Med. 2019 Dec 15;2019:4090549. doi: 10.1155/2019/4090549. eCollection 2019.

DOI:10.1155/2019/4090549
PMID:32089885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7012208/
Abstract

BACKGROUND

Reperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage. Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions.

OBJECTIVE

To investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats.

METHODS

Male Wistar rats were divided into 3 groups: (i) Sham ( = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control ( = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control ( = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (.

RESULTS

Rats treated with vitamin C presented with a similar behavior as compared to the Sham group in all the three tests ( > 0.05), but it was significantly different from controls ( > 0.05), but it was significantly different from controls ( > 0.05), but it was significantly different from controls (.

CONCLUSION

In the present study, vitamin C was associated with behavioral and motor preservation as well as decreased cerebral MDA levels after induced cerebral ischemia in rats.

摘要

背景

颈动脉内膜切除术后再灌注综合征是一种与长期灌注不足的脑半球脑血管自我调节相关的并发症，可导致严重的神经损伤。维生素C是脑代谢中的一种重要抗氧化剂，已显示出一些神经保护作用。

目的

与安慰剂（生理盐水）相比，研究维生素C对大鼠脑再灌注的潜在影响。

方法

雄性Wistar大鼠分为3组：（i）假手术组（n = 4），暴露颈动脉但不夹闭；（ii）对照组（n = 4），暴露颈动脉但不夹闭；（ii）对照组（n = 4），暴露颈动脉但不夹闭；（ii）对照组（。

结果

在所有三项测试中，维生素C治疗的大鼠表现出与假手术组相似的行为（P>0.05），但与对照组有显著差异（P>0.05），但与对照组有显著差异（P>0.05），但与对照组有显著差异（。

结论

在本研究中，维生素C与大鼠脑缺血诱导后的行为和运动保留以及脑MDA水平降低有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/f45f91ccd122/IJVM2019-4090549.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/a99452bb1d51/IJVM2019-4090549.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/2383153b3d41/IJVM2019-4090549.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/872742237162/IJVM2019-4090549.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/8fb28d94df23/IJVM2019-4090549.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/f45f91ccd122/IJVM2019-4090549.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/a99452bb1d51/IJVM2019-4090549.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/2383153b3d41/IJVM2019-4090549.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/872742237162/IJVM2019-4090549.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/8fb28d94df23/IJVM2019-4090549.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b55/7012208/f45f91ccd122/IJVM2019-4090549.005.jpg

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