Angelo Christophe, Vincent Marie-Françoise, Komuta Mina, Hantson Philippe, Straetmans Nicole, Boulet Edwige
Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium.
Department of Clinical Chemistry, Cliniques St-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium.
Case Rep Hematol. 2020 Feb 8;2020:3136074. doi: 10.1155/2020/3136074. eCollection 2020.
Idiopathic hyperammonemia is a rare but potentially fatal complication occurring in patients with acute leukemia or bone marrow transplantation. The role of some specific anticancer drugs may be discussed, but the etiology of hyperammonemia is often multifactorial. We report the case of a 40-year-old woman who developed fatal idiopathic hyperammonemia two weeks after induction chemotherapy with idarubicin-aracytine for acute myeloid leukemia. Despite intensive care management and extrarenal epuration, the patient was declared brain dead two days after hyperammonemia onset.
特发性高氨血症是一种罕见但可能致命的并发症，发生于急性白血病或骨髓移植患者中。某些特定抗癌药物的作用可能会被讨论，但高氨血症的病因通常是多因素的。我们报告了一例40岁女性的病例，该患者在接受伊达比星-阿糖胞苷诱导化疗治疗急性髓系白血病两周后发生了致命的特发性高氨血症。尽管进行了重症监护管理和肾外净化治疗，但患者在高氨血症发作两天后被宣布脑死亡。
