Key Laboratory of Experimental Animal and Safety Evaluation, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Medicine School, Zhejiang University, Hangzhou 310009, China.
Biomed Res Int. 2020 Jan 31;2020:1340153. doi: 10.1155/2020/1340153. eCollection 2020.
Papillary thyroid carcinoma (PTC) is the most common subtype of differentiated thyroid cancers in Asian coastal cities, where the patients have increased risk of potentially high or excessive iodine intake. Given the high metastasis and recurrence of patients with BRAF mutation, the mortality rate of thyroid cancer has recently shown an upward trend. A variety of therapies, including surgery, radiotherapy, and chemotherapy, have been used to treat thyroid cancer, but these therapies still have limitations, including postoperative complications, drug resistance, poor efficacy, or serious side effects. Recent studies have shown the potential of active ingredients derived from herbal medicine in inhibiting PTC via various cell signaling pathways. Some plant-derived compounds, such as apigenin, genistein, and curcumin, are also known to prevent and treat PTC. This article summarizes the recent advances in the structure-functional impact of anti-PTC active ingredients and their effects on PTC cells and tumor microenvironments with an emphasis on their challenges from basic research to clinical practice.
甲状腺乳头状癌（PTC）是亚洲沿海城市分化型甲状腺癌中最常见的亚型，这些地区的患者存在潜在高碘或碘过量摄入的风险。鉴于 BRAF 突变患者具有较高的转移和复发风险，甲状腺癌的死亡率最近呈上升趋势。手术、放疗和化疗等多种疗法已被用于治疗甲状腺癌，但这些疗法仍存在局限性，包括术后并发症、耐药性、疗效不佳或严重的副作用。最近的研究表明，草药活性成分通过多种细胞信号通路抑制 PTC 的潜力。一些植物源性化合物，如芹菜素、染料木黄酮和姜黄素，也被证明可预防和治疗 PTC。本文总结了抗 PTC 活性成分的结构-功能影响及其对 PTC 细胞和肿瘤微环境的作用的最新进展，重点介绍了从基础研究到临床实践所面临的挑战。
