Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Center for Cardiology, Cardiology I - Laboratory of Molecular Cardiology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Int J Mol Sci. 2019 Apr 30;20(9):2155. doi: 10.3390/ijms20092155.
Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing eNOS uncoupling. At the same time, resveratrol inhibits the synthesis of endothelin-1 and reduces oxidative stress in both endothelial cells and smooth muscle cells. Pathological stimuli-induced smooth muscle cell proliferation, vascular remodeling, and arterial stiffness can be ameliorated by resveratrol as well. In addition, resveratrol also modulates immune cell function, inhibition of immune cell infiltration into the vascular wall, and improves the function of perivascular adipose tissue. All these mechanisms contribute to the protective effects of resveratrol on vascular function and blood pressure in vivo. Sirtuin 1, AMP-activated protein kinase, and estrogen receptors represent the major molecules mediating the vascular effects of resveratrol.
白藜芦醇通过上调内皮型一氧化氮合酶（eNOS）的表达、刺激 eNOS 酶活性以及防止 eNOS 解偶联来增加内皮细胞中一氧化氮（NO）的产生。同时，白藜芦醇抑制内皮素-1 的合成，并减少内皮细胞和平滑肌细胞中的氧化应激。白藜芦醇还可以改善病理性刺激诱导的平滑肌细胞增殖、血管重塑和动脉僵硬。此外，白藜芦醇还调节免疫细胞功能，抑制免疫细胞浸润血管壁，并改善血管周围脂肪组织的功能。所有这些机制都有助于白藜芦醇对体内血管功能和血压的保护作用。沉默信息调节因子 1、AMP 激活的蛋白激酶和雌激素受体是介导白藜芦醇血管作用的主要分子。
