Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, King Khalid University, Abha 62529, Asir Region, Saudi Arabia.
Biomed Res Int. 2020 Feb 1;2020:4192745. doi: 10.1155/2020/4192745. eCollection 2020.
Neutrophils comprise the first line of innate immune defense during a host-pathogen interaction. They attack microorganisms directly through three different methods, of which, phagocytosis and degranulation have been known and well-studied for decades. The formation of neutrophil extracellular traps (NETs) is the third and unique method, which was unveiled in 2004. Since then, many studies on NETs have been carried out. However, only few have successfully demonstrated the activity of NETs . Results of the studies on NETs have strengthened our understanding of their role in different situations. This review highlights the main studies, which have contributed in extending our understanding of the role of NETs during infections and diseases, thus indicating their advantages and limitations.
中性粒细胞是宿主-病原体相互作用中先天免疫防御的第一道防线。它们通过三种不同的方法直接攻击微生物，其中吞噬作用和脱颗粒作用已经被人们了解和研究了几十年。中性粒细胞胞外陷阱（NETs）的形成是第三种也是独特的方法，它于 2004 年被揭示。此后，许多关于 NETs 的研究已经开展。然而，只有少数研究成功地证明了 NETs 的活性。NETs 研究的结果加强了我们对它们在不同情况下作用的理解。本综述重点介绍了主要的研究，这些研究有助于我们进一步了解 NETs 在感染和疾病中的作用，从而指出它们的优点和局限性。
