Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Department of Biological Sciences, Faculty of Science, Dar es Salaam University College of Education, Dar es Salaam 2329, Tanzania.
Int J Mol Sci. 2021 Feb 23;22(4):2194. doi: 10.3390/ijms22042194.
Hydrogen sulfide (HS) has long been considered as a toxic gas, but as research progressed, the idea has been updated and it has now been shown to have potent protective effects at reasonable concentrations. HS is an endogenous gas signaling molecule in mammals and is produced by specific enzymes in different cell types. An increasing number of studies indicate that HS plays an important role in cardiovascular homeostasis, and in most cases, HS has been reported to be downregulated in cardiovascular diseases (CVDs). Similarly, in preclinical studies, HS has been shown to prevent CVDs and improve heart function after heart failure. Recently, many HS donors have been synthesized and tested in cellular and animal models. Moreover, numerous molecular mechanisms have been proposed to demonstrate the effects of these donors. In this review, we will provide an update on the role of HS in cardiovascular activities and its involvement in pathological states, with a special focus on the roles of exogenous HS in cardiac protection.
硫化氢 (HS) 长期以来一直被认为是一种有毒气体，但随着研究的进展，这种观点已经得到更新，现在已经表明在合理的浓度下具有强大的保护作用。 HS 是哺乳动物中的内源性气体信号分子，由不同细胞类型中的特定酶产生。越来越多的研究表明 HS 在心血管稳态中发挥重要作用，并且在大多数情况下，HS 已被报道在心血管疾病 (CVD) 中下调。同样，在临床前研究中，HS 已被证明可预防 CVD 并改善心力衰竭后的心脏功能。最近，许多 HS 供体已在细胞和动物模型中合成和测试。此外，还提出了许多分子机制来证明这些供体的作用。在这篇综述中，我们将提供关于 HS 在心血管活动中的作用及其在病理状态下的作用的最新信息，特别关注外源性 HS 在心脏保护中的作用。
