Zou Guoyou, Zheng Minqian, Chen Wang, He Xiao, Cang Dingwei
Department of Orthopedics, the First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Department of Radiology, the First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
J Int Med Res. 2020 Feb;48(2):300060520903636. doi: 10.1177/0300060520903636.
This study was performed to explore the effect of intra-articular injection of autologous platelet-rich plasma (PRP) on refractory pain after low-grade medial collateral ligament (MCL) injury.
In total, 52 patients with refractory pain after low-grade knee MCL injury were treated by intra-articular injection of autologous PRP. Every patient received a 5-mL intra-articular injection of autologous PRP once weekly for 3 weeks. All patients were evaluated by the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form score before treatment and 1, 3, and 6 months after treatment. Magnetic resonance imaging of the knee was performed to observe the healing of the MCL injury 6 months after treatment.
After one injection, the patients’ pain was greatly decreased and they stopped taking nonsteroidal anti-inflammatory drugs. The IKDC Subjective Knee Evaluation Form scores were significantly better after than before treatment; however, there were no significant differences among the various post-treatment time points. Magnetic resonance imaging showed that the low-grade MCL injury had completely healed, and no edema was present around the MCL.
Intra-articular injection of autologous PRP is an effective treatment for refractory pain after low-grade MCL injury.
本研究旨在探讨关节腔内注射自体富血小板血浆（PRP）对低度内侧副韧带（MCL）损伤后顽固性疼痛的影响。
共有52例低度膝关节MCL损伤后出现顽固性疼痛的患者接受了关节腔内注射自体PRP治疗。每位患者每周接受一次5毫升自体PRP关节腔内注射，共注射3周。所有患者在治疗前以及治疗后1、3和6个月均通过国际膝关节文献委员会（IKDC）主观膝关节评估表评分进行评估。在治疗6个月后对膝关节进行磁共振成像，以观察MCL损伤的愈合情况。
注射一次后，患者的疼痛明显减轻，并且停止服用非甾体类抗炎药。治疗后的IKDC主观膝关节评估表评分明显优于治疗前；然而，各治疗后时间点之间没有显著差异。磁共振成像显示低度MCL损伤已完全愈合，MCL周围无水肿。
关节腔内注射自体PRP是治疗低度MCL损伤后顽固性疼痛的有效方法。
