College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, P. R. China.
College of Medicine, Southwest Jiaotong University, Chengdu 610003, China.
J Mater Chem B. 2020 Mar 18;8(11):2199-2215. doi: 10.1039/d0tb00139b.
The regenerative materials for hard tissues, i.e. tooth (enamel, dentin, and cementum) and bone, require extremely high standards in terms of their mechanical properties, biocompatibility, bioactivity, and multiple-functionality. Among them, the biomedical materials inspired from various natural proteins have attracted increasing research attention. These blueprint proteins include various hard-tissue-related proteins, such as collagen and non-collagenous proteins (e.g. amelogenin, dentin phosphoprotein, bone sialoprotein, and osteopontin), as well as other natural proteins like mussel foot proteins. The current review highlights the structure-function relationship of protein bioinspired biomedical materials (e.g. polymers and polypeptides) and their applications for tooth and bone regeneration. Specifically, the materials bioinspired from salivary acquired pellicle proteins, which have a strong affinity to hydroxyapatite surfaces, are discussed in detail. Finally, the challenges associated with these protein bioinspired materials and their industrialization potentials are discussed.
硬组织（牙釉质、牙本质和牙骨质）和骨的再生材料在机械性能、生物相容性、生物活性和多功能性方面需要极高的标准。其中，受各种天然蛋白质启发的生物医学材料引起了越来越多的研究关注。这些蓝图蛋白质包括各种与硬组织相关的蛋白质，如胶原蛋白和非胶原蛋白（例如釉原蛋白、牙本质磷蛋白、骨唾液蛋白和骨桥蛋白），以及其他天然蛋白质，如贻贝类足部蛋白质。本综述重点介绍了蛋白质仿生生物医学材料（如聚合物和多肽）的结构-功能关系及其在牙齿和骨骼再生中的应用。具体来说，详细讨论了受唾液获得性黏膜蛋白启发的材料，这些材料对羟基磷灰石表面具有很强的亲和力。最后，讨论了这些蛋白质仿生材料的挑战及其工业化潜力。
