孕妇的心率变异性和血液学参数。
Heart rate variability and hematological parameters in pregnant women.
机构信息
Unaizah College of Medicine, Qassim University, Unaizah, Saudi Arabia.
Faculty of medicine, Najran University, Saudi Arabia.
出版信息
J Clin Lab Anal. 2020 Jun;34(6):e23250. doi: 10.1002/jcla.23250. Epub 2020 Feb 24.
BACKGROUND
There are few researches on hematological parameters (hemoglobin, red cell distribution width [RDW], white blood cells [WBCs], mean platelets volume [MPV], and heart rate variability [HRV]). There are no published data on this concept (HRV and hematological parameters) during pregnancy.
METHODS
A cross-sectional study was conducted at Saad Abul Ela hospital in Khartoum, Sudan during the period of July to August 2018. Pregnant women with singleton, a live baby, were enrolled in this study. Clinical history and examination were performed. HRV (autonomic modulation) was assessed using time and frequency domain HRV indices.
RESULTS
One hundred and five pregnant women were enrolled. The median (quartile) of the age, parity, and gestational age was 30.0 (25.0-35.0) years, 1.0 (0-3.0), and 38.0 (32.0-39.0) weeks, respectively. While there were positive correlations between hemoglobin and low frequency (LF), RDW and high frequency (HF), WBCs and HF Norm, WBCs and LF/HF, MPV and HF Norm, LF Norm and LF/HF, there was no significant correlation between the hematological (hemoglobin, WBCs, RDW, and MPV) and HRV parameters. Linear regression analysis showed no significant association between age, parity, gestational age, body mass index, hemoglobin, RDW, and HRV variables. The Log WBCs were negatively associated with Log HF (ms /Hz). MPV was positively associated with LF Norm and negatively associated with HF Norm.
CONCLUSION
The study failed to show significant associations between age, parity, gestational age, hemoglobin, RDW, and HRV variables. The WBCs were negatively associated with HF. MPV was positively associated with LF Norm, and it was negatively associated with HF Norm.
背景
关于血液学参数（血红蛋白、红细胞分布宽度[RDW]、白细胞[WBC]、平均血小板体积[MPV]和心率变异性[HRV]）的研究较少。关于这一概念（HRV 和血液学参数）在怀孕期间的研究尚无发表数据。
方法
本研究为 2018 年 7 月至 8 月在苏丹喀土穆的 Saad Abul Ela 医院进行的横断面研究。本研究纳入了单胎活产孕妇。进行了临床病史和检查。使用时域和频域 HRV 指数评估 HRV（自主调节）。
结果
本研究纳入了 105 名孕妇。年龄、产次和妊娠龄的中位数（四分位数间距）分别为 30.0（25.0-35.0）岁、1.0（0-3.0）次和 38.0（32.0-39.0）周。血红蛋白与低频（LF）、RDW 与高频（HF）、WBC 与 HF Norm、WBC 与 LF/HF、MPV 与 HF Norm、LF Norm 与 LF/HF 呈正相关，而血液学参数（血红蛋白、WBC、RDW 和 MPV）与 HRV 参数之间无显著相关性。线性回归分析显示，年龄、产次、妊娠龄、体重指数、血红蛋白、RDW 与 HRV 变量之间无显著相关性。Log WBC 与 Log HF（ms /Hz）呈负相关。MPV 与 LF Norm 呈正相关，与 HF Norm 呈负相关。
结论
本研究未显示年龄、产次、妊娠龄、血红蛋白、RDW 与 HRV 变量之间存在显著相关性。WBC 与 HF 呈负相关。MPV 与 LF Norm 呈正相关，与 HF Norm 呈负相关。
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