Petersen D W
Procter & Gamble Company, Ivorydale Technical Center, Cincinnati, OH 45217.
Food Chem Toxicol. 1988 Sep;26(9):803-6. doi: 10.1016/0278-6915(88)90217-7.
Subchronic percutaneous toxicity studies were conducted on two liquid dishwashing detergents containing anionic surfactants (C12-14 alkylethoxylate sulphate) to assess the safety of these materials for human exposure. The detergents were administered dermally to the shaved backs of rabbits (dose volume of 2 ml/kg body weight) at concentrations of 0, 0.5, 1.0 and 2.5% in distilled water for 91 days. No adverse systemic effects were demonstrated by assessment of haematological parameters or by gross or microscopic tissue examination. Transient slight to moderate dermal irritation at the detergent application site was observed with detergent A. Slight to moderate dermal irritation confined to the detergent application site was noted in the detergent B study.
对两种含有阴离子表面活性剂（C12 - 14烷基乙氧基硫酸盐）的液体餐具洗涤剂进行了亚慢性经皮毒性研究，以评估这些物质对人体暴露的安全性。将洗涤剂以0%、0.5%、1.0%和2.5%的浓度溶于蒸馏水中，以2 ml/kg体重的剂量体积经皮给予背部剃毛的兔子，持续91天。通过血液学参数评估或大体及显微镜组织检查均未发现不良的全身影响。在洗涤剂A的研究中，观察到洗涤剂涂抹部位出现短暂的轻度至中度皮肤刺激。在洗涤剂B的研究中，发现皮肤刺激轻微至中度，局限于洗涤剂涂抹部位。
