Scailteur V, Maurer J K, Walker A P, Calvin G
Food Chem Toxicol. 1986 Feb;24(2):175-81. doi: 10.1016/0278-6915(86)90354-6.
A subchronic oral toxicity study on a model liquid dishwashing detergent containing anionic surfactants was performed to verify that the formulation, made up of a mixture of various ingredients, did not possess any toxicological properties that would not have been expected from available data for each separate ingredient. The product was administered to rats for 13 wk at dietary levels of 0, 0.025, 0.25 or 2.5% (w/w) in the diet. No adverse effects on gross or microscopic histopathology were apparent at any dose level, although increased relative liver weights at the 2.5% level suggested that this dose caused some adaptive changes.
对一种含有阴离子表面活性剂的液体餐具洗涤剂模型进行了亚慢性经口毒性研究，以验证由各种成分混合而成的配方是否具有任何从每种单独成分的现有数据中无法预期的毒理学特性。该产品以0、0.025、0.25或2.5%（w/w）的膳食水平在大鼠饮食中给药13周。在任何剂量水平下，对大体或微观组织病理学均未观察到明显的不良反应，尽管在2.5%剂量水平下相对肝脏重量增加表明该剂量引起了一些适应性变化。
