结核性心包炎的免疫发病机制。
The immunopathogenesis of tuberculous pericarditis.
机构信息
National Heart & Lung Institute, Imperial College London, Guy Scadding Building, Cale Street, London, SW3 6LY, United Kingdom; Department of Medicine, University of Cape Town, Observatory 7925, South Africa.
Department of Medicine, University of Cape Town, Observatory 7925, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.
出版信息
Microbes Infect. 2020 May-Jun;22(4-5):172-181. doi: 10.1016/j.micinf.2020.02.001. Epub 2020 Feb 21.
Tuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8 and 34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in the histology, microbiology and immunology of tuberculous pericarditis, with special focus on the effect of Human Immunodeficiency Virus (HIV) and the determinants of constriction.
结核性心包炎是一种严重的肺外结核形式，是高发地区心包积液的最常见原因。死亡率在 8%至 34%之间，是非洲和亚洲心包缩窄的主要原因。目前对该病的认识是基于上世纪 40 年代至 50 年代进行的研究中得出的模型。本综述总结了结核性心包炎在组织学、微生物学和免疫学方面的最新进展，特别关注了人类免疫缺陷病毒（HIV）的影响和缩窄的决定因素。
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