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保留神经的根治性子宫切除术:短期肿瘤学、手术及功能结局

Nerve Sparing Radical Hysterectomy: Short-Term Oncologic, Surgical, and Functional Outcomes.

作者信息

Muallem Mustafa Zelal, Armbrust Robert, Neymeyer Jörg, Miranda Andrea, Muallem Jumana

机构信息

Department of Gynecology with Center for Oncological Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, 13353 Berlin, Germany.

Department of urology, Mitte Campus Clinic, Charité Medical University, 10117 Berlin, Germany.

出版信息

Cancers (Basel). 2020 Feb 19;12(2):483. doi: 10.3390/cancers12020483.

Abstract

There is an obvious prevalence of disparity in opinions concerning the technique of nerve-sparing radical hysterectomy and its application, despite agreement on the need to spare the pelvic autonomic nerve system during such a radical operation. Understanding the precise three-dimensional anatomy of paracolpium and its close anatomical relationship to the components of the pelvic autonomic nervous system is the key in performing the nerve-sparing radical hysterectomy. A total of 42 consecutive patients with primary cervical cancers, who were operated upon in our institution between January 2017 and June 2019, were analyzed, concerning surgical, urinary functional, and short-term oncologic outcomes. Two thirds of the patients had locally advanced tumors (T > 40 mm or pT ≥ IIA2) with a median tumor size of 44.1 mm. The nerve-sparing radical hysterectomy was combined with the complete recovery of bladder function in 90% of patients directly after surgery and in 97% of patients in the first 2 weeks. The recurrence rate in a median follow-up time of 18 months was 9.5%. The nerve-sparing radical hysterectomy approach, which depends on the comprehensive understanding of the precise entire anatomy of paracolpium, was found to be feasible and applicable, even in locally advanced tumors, with good functional results and convincing short-term oncologic outcomes.

摘要

尽管在根治性手术中需要保留盆腔自主神经系统这一点上已达成共识,但在保留神经的根治性子宫切除术技术及其应用方面,意见存在明显分歧。了解阴道旁组织精确的三维解剖结构及其与盆腔自主神经系统各组成部分的紧密解剖关系是实施保留神经的根治性子宫切除术的关键。对2017年1月至2019年6月间在本机构接受手术的42例原发性宫颈癌患者的手术、泌尿功能及短期肿瘤学结果进行了分析。三分之二的患者患有局部晚期肿瘤(肿瘤直径T>40mm或pT≥IIA2),肿瘤中位大小为44.1mm。保留神经的根治性子宫切除术后,90%的患者术后膀胱功能立即完全恢复,97%的患者在术后前两周内膀胱功能完全恢复。中位随访时间18个月时的复发率为9.5%。结果发现,即使对于局部晚期肿瘤,基于对阴道旁组织精确整体解剖结构全面理解的保留神经的根治性子宫切除术方法也是可行且适用的,其功能效果良好,短期肿瘤学结果令人信服。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cee/7072686/6eab00aae721/cancers-12-00483-g001.jpg

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