KGK Science, London, ON N6A 5R8, Canada.
Standard Process Inc, Palmyra, WI 53156, USA.
Nutrients. 2020 Feb 20;12(2):540. doi: 10.3390/nu12020540.
A-F Betafood is a whole food-based health product. The product contains phytonutrients and bioactives with antioxidant properties that may support gallbladder and liver function. Herein, we investigated the efficacy of A-F Betafood on gallbladder and liver function. In this randomized, placebo-controlled, parallel study fifty overweight but otherwise healthy adults received A-F Betafood or placebo for 12 weeks. Gallbladder function as assessed by gallbladder volume, ejection fraction (GBEF), ejection rate, wall thickness and liver function determined via aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase, and high-sensitivity c-reactive protein analysis at baseline and week 12 were the primary outcomes. Total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, triglycerides, and oxidative stress markers including oxidized low-density lipoprotein, tumor necrosis factor-α, adiponectin and malonyldialdehyde (MDA) were assessed as secondary outcomes. A-F Betafood-supplementation significantly reduced gallbladder wall thickness ( = 0.049) by 9% compared to placebo from baseline to week 12. The A-F Betafood group alone had significant improvements in gallbladder volume (32%; = 0.044) and GBEF (19%; = 0.047) at week 12. There were no changes in liver function, oxidative stress markers or blood lipid concentrations, though MDA concentrations decreased in both groups. Our findings demonstrate A-F Betafood-supplementation significantly improves measures of gallbladder function and support healthy gallbladder function in the individuals with gall bladder condition.
A-F Betafood 是一种全食物基础的健康产品。该产品含有具有抗氧化特性的植物营养素和生物活性物质，可能有助于支持胆囊和肝功能。在此，我们研究了 A-F Betafood 对胆囊和肝功能的功效。在这项随机、安慰剂对照、平行研究中，五十名超重但其他方面健康的成年人接受了 A-F Betafood 或安慰剂治疗，为期 12 周。通过胆囊体积、射血分数（GBEF）、射血率、壁厚度和天门冬氨酸氨基转移酶、丙氨酸氨基转移酶和γ-谷氨酰转移酶以及超敏 C 反应蛋白分析评估的胆囊功能，以及总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯和氧化应激标志物，包括氧化低密度脂蛋白、肿瘤坏死因子-α、脂联素和丙二醛（MDA），作为次要结果。从基线到第 12 周，与安慰剂相比，A-F Betafood 补充剂可使胆囊壁厚度显著降低（=0.049），降低 9%。仅 A-F Betafood 组在第 12 周时胆囊体积（32%；=0.044）和 GBEF（19%；=0.047）有显著改善。肝功能、氧化应激标志物或血脂浓度没有变化，尽管两组 MDA 浓度均降低。我们的研究结果表明，A-F Betafood 补充剂可显著改善胆囊功能的测量，并支持患有胆囊疾病的个体的健康胆囊功能。
