Department of General Surgery, Xuanwu Hospital, The First Clinical Medical College, Capital Medical University, No.45 Changchun Street, Beijing, China.
Vascular Surgery Department, Xuanwu Hospital, The First Clinical Medical College, Capital Medical University, Beijing, China.
Lipids Health Dis. 2021 Mar 22;20(1):26. doi: 10.1186/s12944-021-01452-6.
The purpose of this study was to assess the risk factors for cholesterol polyp formation in the gallbladder.
This was a multicenter retrospective study based on pathology. From January 2016 to December 2019, patients who underwent cholecystectomy and non-polyp participants confirmed by continuous ultrasound follow-ups were reviewed. Patients in the cholesterol polyp group were recruited from three high-volume centers with a diagnosis of pathologically confirmed cholesterol polyps larger than 10 mm. Population characteristics and medical data were collected within 24 h of admission before surgery. The non-polyp group included participants from the hospital physical examination center database. They had at least two ultrasound examinations with an interval longer than 180 days. Data from the final follow-up of the non-polyp group were analyzed. The risk factors for cholesterol polyp formation were analyzed by comparing the two groups.
A total of 4714 participants were recruited, including 376 cholesterol polyp patients and 4338 non-polyp participants. In univariate analysis, clinical risk factors for cholesterol polyps were age, male sex, higher body mass index (BMI), higher low-density lipoprotein (LDL), lower high-density lipoprotein (HDL), and higher aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. In multivariate logistic analysis, independent risk factors were age > 50 years (odds ratio [OR] = 3.02, 95% confidence interval [CI] 2.33-3.91, P < 0.001], LDL > 2.89 mmol/L (OR = 1.38, 95% CI 1.08-1.78, P = 0.011), lower HDL (OR = 1.78 95% CI 1.32-2.44, P < 0.001), AST > 40 IU/L (OR = 3.55, 95% CI 2.07-6.07, P < 0.001), and BMI > 25 kg/m (OR = 1.32, 95% CI 1.01-1.72, P = 0.037).
Age, LDL, HDL, AST, and BMI are strong risk factors for cholesterol polyp formation. Older overweight patients with polyps, accompanied by abnormal lipid levels, are at high risk for cholesterol polyps.
本研究旨在评估胆囊胆固醇息肉形成的危险因素。
这是一项基于病理学的多中心回顾性研究。2016 年 1 月至 2019 年 12 月，对接受胆囊切除术且经连续超声随访证实无息肉的患者进行了回顾性分析。胆固醇息肉组患者来自三家高容量中心，病理诊断为大于 10mm 的胆固醇息肉。在手术前 24 小时内收集人口统计学特征和医疗数据。非息肉组包括来自医院体检中心数据库的参与者。他们至少有两次超声检查，间隔大于 180 天。对非息肉组的最后一次随访进行分析。通过比较两组，分析胆固醇息肉形成的危险因素。
共纳入 4714 名参与者，包括 376 名胆固醇息肉患者和 4338 名非息肉患者。单因素分析显示，胆固醇息肉的临床危险因素为年龄、男性、较高的体重指数（BMI）、较低的高密度脂蛋白（HDL）、较高的天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平。多因素 logistic 分析显示，年龄>50 岁（比值比[OR] 3.02，95%置信区间[CI] 2.33-3.91，P<0.001）、LDL>2.89mmol/L（OR 1.38，95%CI 1.08-1.78，P=0.011）、HDL 较低（OR 1.78，95%CI 1.32-2.44，P<0.001）、AST>40IU/L（OR 3.55，95%CI 2.07-6.07，P<0.001）和 BMI>25kg/m （OR 1.32，95%CI 1.01-1.72，P=0.037）是胆固醇息肉形成的独立危险因素。
年龄、LDL、HDL、AST 和 BMI 是胆固醇息肉形成的强危险因素。年龄较大、超重且伴有血脂异常的患者发生胆固醇息肉的风险较高。
