Vales Temmy Pegarro, Jee Jun-Pil, Lee Won Young, Cho Sung, Lee Gye Myung, Kim Ho-Joong, Kim Jung Suk
Department of Chemistry, Chosun University, Gwangju 501-759, Korea.
Department of Natural Sciences, Caraga State University, Butuan City 8600, Philippines.
Materials (Basel). 2020 Feb 20;13(4):943. doi: 10.3390/ma13040943.
A series of hydrogels with intrinsic antifouling properties was prepared via surface-functionalization of poly(2-hydroxyethyl methacrylate) [p(HEMA)]-based hydrogels with the biomembrane-mimicking zwitterionic polymer, poly(2-methacryloyloxyethyl phosphorylcholine) [p(MPC)]. The p(MPC)-modified hydrogels have enhanced surface wettability, high water content retention (61.0%-68.3%), and good transmittance (>90%). Notably, the presence of zwitterionic MPC moieties at the hydrogel surfaces lowered the adsorption of proteins such as lysozyme and bovine serum albumin (BSA) by 73%-74% and 59%-66%, respectively, and reduced bacterial adsorption by approximately 10%-73% relative to the unmodified control. The anti-biofouling properties of the p(MPC)-functionalized hydrogels are largely attributed to the dense hydration layer formed at the hydrogel surfaces by the zwitterionic moieties. Overall, the results demonstrate that biocompatible and antifouling hydrogels based on p(HEMA)-p(MPC) structures have promising potential for application in biomedical materials.
通过用具有生物膜模拟功能的两性离子聚合物聚（2-甲基丙烯酰氧乙基磷酰胆碱）[p(MPC)]对聚（甲基丙烯酸2-羟乙酯）[p(HEMA)]基水凝胶进行表面功能化，制备了一系列具有固有抗污性能的水凝胶。p(MPC)改性水凝胶具有增强的表面润湿性、高含水量保持率（61.0%-68.3%）和良好的透光率（>90%）。值得注意的是，水凝胶表面两性离子MPC基团的存在使溶菌酶和牛血清白蛋白（BSA）等蛋白质的吸附分别降低了73%-74%和59%-66%，并且相对于未改性的对照，细菌吸附减少了约10%-73%。p(MPC)功能化水凝胶的抗生物污损性能很大程度上归因于两性离子基团在水凝胶表面形成的致密水合层。总体而言，结果表明基于p(HEMA)-p(MPC)结构的生物相容性和抗污性水凝胶在生物医学材料应用方面具有广阔的前景。
