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[非小细胞肺癌局部热消融的进展与挑战]

[Advances and Challenges of Local Thermal Ablation in Non-small Cell Lung Cancer].

作者信息

Gou Qing, Zhou Zejian, Zhao Mingfang, Chen Xiaoming, Zhou Qing

机构信息

Department of Interventional Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510080, China.

The First Hospital of China Medical University, Department of Medical Oncology, Shenyang 110001, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2020 Feb 20;23(2):111-117. doi: 10.3779/j.issn.1009-3419.2020.02.06.

DOI:10.3779/j.issn.1009-3419.2020.02.06
PMID:32093455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7049787/
Abstract

Non-small cell lung cancer (NSCLC) is the most common pathological type of primary lung cancer. Currently, main treatment approaches for NSCLC patients include surgical resection, radiotherapy, chemotherapy, targeted therapy and so on. In recent years, thermal ablation has received increasing attention in the treatment of various stages of NSCLC. As a safe and efficient local treatment, thermal ablation may bring potential clinical benefits to NSCLC patients. However, many issues remain unsolved and further investigation is needed in the clinical application of thermal ablation in NSCLC. In this review, we aim to summarize the applications of thermal ablation in NSCLC and further discuss the emerging controversies as well as future research directions.

摘要

非小细胞肺癌(NSCLC)是原发性肺癌最常见的病理类型。目前,NSCLC患者的主要治疗方法包括手术切除、放疗、化疗、靶向治疗等。近年来,热消融在NSCLC各阶段治疗中受到越来越多的关注。作为一种安全有效的局部治疗方法,热消融可能给NSCLC患者带来潜在的临床益处。然而,许多问题仍未解决,热消融在NSCLC临床应用中仍需进一步研究。在本综述中,我们旨在总结热消融在NSCLC中的应用,并进一步讨论新出现的争议以及未来的研究方向。

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Am J Transl Res. 2023 Apr 15;15(4):2939-2948. eCollection 2023.
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Front Immunol. 2022 Aug 12;13:969447. doi: 10.3389/fimmu.2022.969447. eCollection 2022.
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本文引用的文献

1
Efficacy and safety of microwave ablation in the treatment of patients with oligometastatic non-small-cell lung cancer: a retrospective study.微波消融治疗寡转移非小细胞肺癌患者的疗效和安全性:一项回顾性研究。
Int J Hyperthermia. 2019;36(1):827-834. doi: 10.1080/02656736.2019.1642522.
2
Microwave ablation combined with chemotherapy improved progression free survival of IV stage lung adenocarcinoma patients compared with chemotherapy alone.微波消融联合化疗较单纯化疗改善 IV 期肺腺癌患者无进展生存期。
Thorac Cancer. 2019 Jul;10(7):1628-1635. doi: 10.1111/1759-7714.13129. Epub 2019 Jun 27.
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Radiofrequency ablation of liver metastasis: potential impact on immune checkpoint inhibitor therapy.射频消融治疗肝转移瘤:对免疫检查点抑制剂治疗的潜在影响。
Eur Radiol. 2019 Sep;29(9):5045-5051. doi: 10.1007/s00330-019-06189-6. Epub 2019 Apr 8.
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Cancer statistics, 2019.癌症统计数据,2019 年。
CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.
5
Survival Rates after Thermal Ablation versus Stereotactic Radiation Therapy for Stage 1 Non-Small Cell Lung Cancer: A National Cancer Database Study.Ⅰ期非小细胞肺癌行热消融与立体定向放疗的生存率比较:一项国家癌症数据库研究。
Radiology. 2018 Dec;289(3):862-870. doi: 10.1148/radiol.2018180979. Epub 2018 Sep 18.
6
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018:GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
7
Radiofrequency ablation of stage IA non-small cell lung cancer in patients ineligible for surgery: results of a prospective multicenter phase II trial.无法进行手术的IA期非小细胞肺癌患者的射频消融治疗:一项前瞻性多中心II期试验的结果
J Cardiothorac Surg. 2018 Aug 24;13(1):91. doi: 10.1186/s13019-018-0773-y.
8
Expert consensus workshop report: Guidelines for thermal ablation of primary and metastatic lung tumors (2018 edition).专家共识研讨会报告:原发性和转移性肺肿瘤热消融指南(2018年版)
J Cancer Res Ther. 2018;14(4):730-744. doi: 10.4103/jcrt.JCRT_221_18.
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Microwave ablation with continued EGFR tyrosine kinase inhibitor therapy prolongs disease control in non-small-cell lung cancers with acquired resistance to EGFR tyrosine kinase inhibitors.微波消融联合持续 EGFR 酪氨酸激酶抑制剂治疗延长 EGFR 酪氨酸激酶抑制剂获得性耐药的非小细胞肺癌患者的疾病控制时间。
Thorac Cancer. 2018 Aug;9(8):1012-1017. doi: 10.1111/1759-7714.12779. Epub 2018 Jun 20.
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Intraprocedural Ablation Margin Assessment by Using Ammonia Perfusion PET during FDG PET/CT-guided Liver Tumor Ablation: A Pilot Study.使用 FDG PET/CT 引导下肝肿瘤消融时氨灌注 PET 进行术中消融边缘评估:一项初步研究。
Radiology. 2018 Jul;288(1):138-145. doi: 10.1148/radiol.2018172108. Epub 2018 Apr 3.